Landomycin A inhibits DNA synthesis and G1/S cell cycle progression

Robert T. Crow; Betty Rosenbaum; Roger Smith; Yu Guo; Kenneth S. Ramos; Gary A. Sulikowski

doi:10.1016/S0960-894X(99)00261-9

Landomycin A inhibits DNA synthesis and G₁/S cell cycle progression

Robert T. Crow, Betty Rosenbaum, Roger Smith, Yu Guo, Kenneth S. Ramos, Gary A. Sulikowski

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Landomycin A was found to inhibit the uptake of [³H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.

Original language	English (US)
Pages (from-to)	1663-1666
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(99)00261-9
State	Published - Jun 21 1999
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00261-9

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title = "Landomycin A inhibits DNA synthesis and G1/S cell cycle progression",

abstract = "Landomycin A was found to inhibit the uptake of [3H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.",

author = "Crow, {Robert T.} and Betty Rosenbaum and Roger Smith and Yu Guo and Ramos, {Kenneth S.} and Sulikowski, {Gary A.}",

note = "Funding Information: AcknowledgmentTsh: is work was supportebd y the AmericanC ancerS ociety( DHP-154)a nd the Welch Foundatio(nA -1230)W. e arei ndebtedto ProfessoJru rgenR ohr( MedicalU niversityo f SouthC arolina)fo r the generougs ift of landomcyinA and thankJ . Kevin Kerzeef or advicea ndh elpfulc ommentsG. . A. S. is an Alfred P. SloanF ellow( 1996-1998a)n dE li Lilly Grantee(1 996-1998).",

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doi = "10.1016/S0960-894X(99)00261-9",

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T1 - Landomycin A inhibits DNA synthesis and G1/S cell cycle progression

AU - Crow, Robert T.

AU - Rosenbaum, Betty

AU - Smith, Roger

AU - Guo, Yu

AU - Ramos, Kenneth S.

AU - Sulikowski, Gary A.

N1 - Funding Information: AcknowledgmentTsh: is work was supportebd y the AmericanC ancerS ociety( DHP-154)a nd the Welch Foundatio(nA -1230)W. e arei ndebtedto ProfessoJru rgenR ohr( MedicalU niversityo f SouthC arolina)fo r the generougs ift of landomcyinA and thankJ . Kevin Kerzeef or advicea ndh elpfulc ommentsG. . A. S. is an Alfred P. SloanF ellow( 1996-1998a)n dE li Lilly Grantee(1 996-1998).

PY - 1999/6/21

Y1 - 1999/6/21

N2 - Landomycin A was found to inhibit the uptake of [3H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.

AB - Landomycin A was found to inhibit the uptake of [3H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

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ER -

Landomycin A inhibits DNA synthesis and G₁/S cell cycle progression

Abstract

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