Landomycin A inhibits DNA synthesis and G1/S cell cycle progression

Robert T. Crow, Betty Rosenbaum, Roger Smith, Yu Guo, Kenneth Ramos, Gary A. Sulikowski

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Landomycin A was found to inhibit the uptake of [3H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.

Original languageEnglish (US)
Pages (from-to)1663-1666
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number12
DOIs
StatePublished - Jun 21 1999
Externally publishedYes

Fingerprint

Cell Cycle
Cells
DNA
Thymidine
Smooth Muscle Myocytes
Muscle
landomycin A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Landomycin A inhibits DNA synthesis and G1/S cell cycle progression. / Crow, Robert T.; Rosenbaum, Betty; Smith, Roger; Guo, Yu; Ramos, Kenneth; Sulikowski, Gary A.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 12, 21.06.1999, p. 1663-1666.

Research output: Contribution to journalArticle

Crow, Robert T. ; Rosenbaum, Betty ; Smith, Roger ; Guo, Yu ; Ramos, Kenneth ; Sulikowski, Gary A. / Landomycin A inhibits DNA synthesis and G1/S cell cycle progression. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 12. pp. 1663-1666.
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