Landomycin A inhibits DNA synthesis and G1/S cell cycle progression

Robert T. Crow, Betty Rosenbaum, Roger Smith, Yu Guo, Kenneth S. Ramos, Gary A. Sulikowski

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Landomycin A was found to inhibit the uptake of [3H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.

Original languageEnglish (US)
Pages (from-to)1663-1666
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number12
DOIs
StatePublished - Jun 21 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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