Laparoscopic optical coherence tomographic imaging of human ovarian cancer

Lida P. Hariri, Garret T. Bonnema, Kathy Schmidt, Kenneth Hatch, Molly Brewer, Jennifer K. Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Ovarian cancer is the fourth leading cause of cancer-related death among women in the United States. If diagnosed at an early stage, the 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of all cases are diagnosed at the early, localized stage. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 microns) at imaging depths up to 2 mm. Previously, we studied OCT imaging in normal and diseased human ovary ex vivo to determine the features OCT is capable of resolving. Changes in collagen were suggested with several of the images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated specifically for in vivo laparoscopic imaging. The LOCT probe consists of a 38 mm diameter handpiece terminated in an 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar and is capable of obtaining up to 9.5 mm image lengths at 10 micron axial resolution. In this study, we utilize the LOCT probe to image one or both ovaries of 20 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of identifying and/or differentiating normal and neoplastic ovary. To date, we have laparoscopically imaged the ovaries of ten patients successfully with no known complications..

Original languageEnglish (US)
Title of host publicationEndoscopic Microscopy III
DOIs
StatePublished - Apr 21 2008
EventEndoscopic Microscopy III - San Jose, CA, United States
Duration: Jan 20 2008Jan 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6851
ISSN (Print)1605-7422

Other

OtherEndoscopic Microscopy III
CountryUnited States
CitySan Jose, CA
Period1/20/081/21/08

Keywords

  • Laparoscocpy
  • Optical coherence tomography
  • Ovarian cancer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Hariri, L. P., Bonnema, G. T., Schmidt, K., Hatch, K., Brewer, M., & Barton, J. K. (2008). Laparoscopic optical coherence tomographic imaging of human ovarian cancer. In Endoscopic Microscopy III [685107] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6851). https://doi.org/10.1117/12.760995