Laparoscopic optical coherence tomographic imaging of human ovarian cancer

Lida P. Hariri, Garret T. Bonnema, Kathy Schmidt, Vrushali Korde, Amy M. Winkler, Kenneth D Hatch, Molly Brewer, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ovarian cancer is the fourth leading cause of cancer-related death among women. If diagnosed at early stages, 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of cases are diagnosed at early, localized stages. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 μm) at imaging depths up to 2 mm. Previously, we studied OCT in normal and diseased human ovary ex vivo. Changes in collagen were suggested with several images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated for in vivo imaging. The LOCT probe, consisting of a 38 mm diameter handpiece terminated in a 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar, is capable of obtaining up to 9.5 mm image lengths at 10 μm axial resolution. In this pilot study, we utilize the LOCT probe to image one or both ovaries of 17 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of differentiating normal and neoplastic ovary. We have laparoscopically imaged the ovaries of seventeen patients with no known complications. Initial data evaluation reveals qualitative distinguishability between the features of undiseased post-menopausal ovary and the cystic, non-homogenous appearance of neoplastic ovary such as serous cystadenoma and endometroid adenocarcinoma.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7169
DOIs
StatePublished - 2009
EventAdvanced Biomedical and Clinical Diagnostic Systems VII - San Jose, CA, United States
Duration: Jan 25 2009Jan 26 2009

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems VII
CountryUnited States
CitySan Jose, CA
Period1/25/091/26/09

Fingerprint

Ovarian Cancer
ovaries
Ovary
cancer
Imaging
Imaging techniques
Collagen
Probe
Endoscopy
Optical tomography
Blood vessels
collagens
probes
Tissue
Necrosis
Optical Coherence Tomography
Metastasis
necrosis
Blood Vessels
blood vessels

Keywords

  • Laparoscopy
  • Optical coherence tomography
  • Ovarian cancer
  • Transabdominal endoscopy

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Hariri, L. P., Bonnema, G. T., Schmidt, K., Korde, V., Winkler, A. M., Hatch, K. D., ... Barton, J. K. (2009). Laparoscopic optical coherence tomographic imaging of human ovarian cancer. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7169). [71690S] https://doi.org/10.1117/12.809167

Laparoscopic optical coherence tomographic imaging of human ovarian cancer. / Hariri, Lida P.; Bonnema, Garret T.; Schmidt, Kathy; Korde, Vrushali; Winkler, Amy M.; Hatch, Kenneth D; Brewer, Molly; Barton, Jennifer K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7169 2009. 71690S.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hariri, LP, Bonnema, GT, Schmidt, K, Korde, V, Winkler, AM, Hatch, KD, Brewer, M & Barton, JK 2009, Laparoscopic optical coherence tomographic imaging of human ovarian cancer. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7169, 71690S, Advanced Biomedical and Clinical Diagnostic Systems VII, San Jose, CA, United States, 1/25/09. https://doi.org/10.1117/12.809167
Hariri LP, Bonnema GT, Schmidt K, Korde V, Winkler AM, Hatch KD et al. Laparoscopic optical coherence tomographic imaging of human ovarian cancer. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7169. 2009. 71690S https://doi.org/10.1117/12.809167
Hariri, Lida P. ; Bonnema, Garret T. ; Schmidt, Kathy ; Korde, Vrushali ; Winkler, Amy M. ; Hatch, Kenneth D ; Brewer, Molly ; Barton, Jennifer K. / Laparoscopic optical coherence tomographic imaging of human ovarian cancer. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7169 2009.
@inproceedings{311494f6a35b4004b913f5ab103c4072,
title = "Laparoscopic optical coherence tomographic imaging of human ovarian cancer",
abstract = "Ovarian cancer is the fourth leading cause of cancer-related death among women. If diagnosed at early stages, 5-year survival rate is 94{\%}, but drops to 68{\%} for regional disease and 29{\%} for distant metastasis; only 19{\%} of cases are diagnosed at early, localized stages. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 μm) at imaging depths up to 2 mm. Previously, we studied OCT in normal and diseased human ovary ex vivo. Changes in collagen were suggested with several images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated for in vivo imaging. The LOCT probe, consisting of a 38 mm diameter handpiece terminated in a 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar, is capable of obtaining up to 9.5 mm image lengths at 10 μm axial resolution. In this pilot study, we utilize the LOCT probe to image one or both ovaries of 17 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of differentiating normal and neoplastic ovary. We have laparoscopically imaged the ovaries of seventeen patients with no known complications. Initial data evaluation reveals qualitative distinguishability between the features of undiseased post-menopausal ovary and the cystic, non-homogenous appearance of neoplastic ovary such as serous cystadenoma and endometroid adenocarcinoma.",
keywords = "Laparoscopy, Optical coherence tomography, Ovarian cancer, Transabdominal endoscopy",
author = "Hariri, {Lida P.} and Bonnema, {Garret T.} and Kathy Schmidt and Vrushali Korde and Winkler, {Amy M.} and Hatch, {Kenneth D} and Molly Brewer and Barton, {Jennifer K}",
year = "2009",
doi = "10.1117/12.809167",
language = "English (US)",
volume = "7169",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Laparoscopic optical coherence tomographic imaging of human ovarian cancer

AU - Hariri, Lida P.

AU - Bonnema, Garret T.

AU - Schmidt, Kathy

AU - Korde, Vrushali

AU - Winkler, Amy M.

AU - Hatch, Kenneth D

AU - Brewer, Molly

AU - Barton, Jennifer K

PY - 2009

Y1 - 2009

N2 - Ovarian cancer is the fourth leading cause of cancer-related death among women. If diagnosed at early stages, 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of cases are diagnosed at early, localized stages. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 μm) at imaging depths up to 2 mm. Previously, we studied OCT in normal and diseased human ovary ex vivo. Changes in collagen were suggested with several images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated for in vivo imaging. The LOCT probe, consisting of a 38 mm diameter handpiece terminated in a 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar, is capable of obtaining up to 9.5 mm image lengths at 10 μm axial resolution. In this pilot study, we utilize the LOCT probe to image one or both ovaries of 17 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of differentiating normal and neoplastic ovary. We have laparoscopically imaged the ovaries of seventeen patients with no known complications. Initial data evaluation reveals qualitative distinguishability between the features of undiseased post-menopausal ovary and the cystic, non-homogenous appearance of neoplastic ovary such as serous cystadenoma and endometroid adenocarcinoma.

AB - Ovarian cancer is the fourth leading cause of cancer-related death among women. If diagnosed at early stages, 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of cases are diagnosed at early, localized stages. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 μm) at imaging depths up to 2 mm. Previously, we studied OCT in normal and diseased human ovary ex vivo. Changes in collagen were suggested with several images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated for in vivo imaging. The LOCT probe, consisting of a 38 mm diameter handpiece terminated in a 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar, is capable of obtaining up to 9.5 mm image lengths at 10 μm axial resolution. In this pilot study, we utilize the LOCT probe to image one or both ovaries of 17 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of differentiating normal and neoplastic ovary. We have laparoscopically imaged the ovaries of seventeen patients with no known complications. Initial data evaluation reveals qualitative distinguishability between the features of undiseased post-menopausal ovary and the cystic, non-homogenous appearance of neoplastic ovary such as serous cystadenoma and endometroid adenocarcinoma.

KW - Laparoscopy

KW - Optical coherence tomography

KW - Ovarian cancer

KW - Transabdominal endoscopy

UR - http://www.scopus.com/inward/record.url?scp=66249096688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66249096688&partnerID=8YFLogxK

U2 - 10.1117/12.809167

DO - 10.1117/12.809167

M3 - Conference contribution

AN - SCOPUS:66249096688

VL - 7169

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -