Laparoscopic optical coherence tomographic imaging of human ovarian cancer

Lida P. Hariri, Garret T. Bonnema, Kathy Schmidt, Vrushali Korde, Amy M. Winkler, Kenneth Hatch, Molly Brewer, Jennifer K. Barton

Research output: Contribution to journalConference article

Abstract

Ovarian cancer is the fourth leading cause of cancer-related death among women. If diagnosed at early stages, 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of cases are diagnosed at early, localized stages. Optical coherence tomography is a recently emerging non-destructive imaging technology, achieving high axial resolutions (10-20 μm) at imaging depths up to 2 mm. Previously, we studied OCT in normal and diseased human ovary ex vivo. Changes in collagen were suggested with several images that correlated with changes in collagen seen in malignancy. Areas of necrosis and blood vessels were also visualized using OCT, indicative of an underlying tissue abnormality. We recently developed a custom side-firing laparoscopic OCT (LOCT) probe fabricated for in vivo imaging. The LOCT probe, consisting of a 38 mm diameter handpiece terminated in a 280 mm long, 4.6 mm diameter tip for insertion into the laparoscopic trocar, is capable of obtaining up to 9.5 mm image lengths at 10 μm axial resolution. In this pilot study, we utilize the LOCT probe to image one or both ovaries of 17 patients undergoing laparotomy or transabdominal endoscopy and oophorectomy to determine if OCT is capable of differentiating normal and neoplastic ovary. We have laparoscopically imaged the ovaries of seventeen patients with no known complications. Initial data evaluation reveals qualitative distinguishability between the features of undiseased post-menopausal ovary and the cystic, non-homogenous appearance of neoplastic ovary such as serous cystadenoma and endometroid adenocarcinoma.

Original languageEnglish (US)
Article number71690S
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7169
DOIs
StatePublished - Jun 8 2009
EventAdvanced Biomedical and Clinical Diagnostic Systems VII - San Jose, CA, United States
Duration: Jan 25 2009Jan 26 2009

Keywords

  • Laparoscopy
  • Optical coherence tomography
  • Ovarian cancer
  • Transabdominal endoscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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