Large monodomain bilayer arrays

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Described is a summary of methods to produce large monodomain bilayer arrays which contain a host of bioelectronic molecules between two supports such as glass, metal, or metal oxide surfaces. The methods involve the use of soap-based or silane polymer surfactants to render the contacting surfaces hydrophobic. The bilayer composition can be pure lipid; mixtures of lipid and protein, antibiotics, etc.; or purified proteins with bound lipid. Stacking of successive bilayers (or multiples of bilayers) having different copositions can be achieved by successive stages of annealing or shearing before adjustment of hydration. With these techniques, monodomain areas of approximately 1 cm2 and up to 500 μm thick can be achieved having a high density of bioelectronic molecules and varied composition.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Number of pages1
Editionpt 4
ISBN (Print)0879425598
StatePublished - Dec 1 1990
Externally publishedYes
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 4
ISSN (Print)0589-1019

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

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ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Powers, L. (1990). Large monodomain bilayer arrays. In Biomedical Engineering Perspectives: Health Care Technologies for the 1990's and Beyond (pt 4 ed.). (Proceedings of the Annual Conference on Engineering in Medicine and Biology; No. pt 4). Publ by IEEE.