Laser treatment of port wine stains

Three-dimensional simulation using a biopsy-defined geometry in an optical-thermal model

T. Joshua Pfefer, Jennifer K Barton, Derek J. Smithies, Thomas E. Milner, J. Stuart Nelson, Martin J C Van Gemert, A. J. Welch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

The efficacy of laser treatment of port wine stains (PWS) has been shown to be highly dependent on the patient-specific structure of vascular lesions. To improve the accuracy of PWS numerical models, an optical-thermal model simulating an arbitrarily complex, three dimensional tissue geometry has been developed. In this model, the distribution of absorbed radiant energy - determined using a modified Monte Carlo technique - is used as the source term in a finite difference thermal model that predicts transient temperature rise. The Arrhenius rate process integral is then used to calculate thermal damage. Simulations based on a tomographic reconstruction of a PWS biopsy were performed for laser pulse durations of 0.5, 5.0 and 50.0 ms and a wavelength of 585 nm. Irradiances that produced maximum tissue temperatures of 120 °C were used. The simulations indicated that energy deposition in blood is primarily a function of depth in skin. Thermal diffusion effects increased with longer pulse duration, leading to collateral damage observed at 5.0 and 50.0 ms. A pulse duration of 0.5 ms resulted in confinement of thermal damage to blood regions. Clusters of small vessels tended to behave similarly to larger vessels, reaching higher temperatures and creating more damage in the surrounding dermis than isolated vessels. The incorporation of realistic geometry into an optical-thermal model represents a significant advance in computer modeling of laser surgery.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsR.R. Anderson, K.E. Bartels, L.S. Bass, C.G. Garrett
Pages322-333
Number of pages12
Volume3245
DOIs
StatePublished - 1997
Externally publishedYes
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII - San Jose, CA, United States
Duration: Jan 24 1998Jan 25 1998

Other

OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII
CountryUnited States
CitySan Jose, CA
Period1/24/981/25/98

Fingerprint

wines
Wine
Biopsy
Geometry
Lasers
damage
vessels
geometry
pulse duration
lasers
simulation
blood
Blood
Laser surgery
Tissue
Thermal diffusion
thermal diffusion
irradiance
surgery
lesions

Keywords

  • Arrhenius integral
  • Finite difference
  • Heat transfer
  • Laser surgery
  • Monte Carlo
  • Numerical modeling
  • Optical
  • Port wine stains
  • Thermal damage
  • Tissue reconstruction

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Pfefer, T. J., Barton, J. K., Smithies, D. J., Milner, T. E., Nelson, J. S., Van Gemert, M. J. C., & Welch, A. J. (1997). Laser treatment of port wine stains: Three-dimensional simulation using a biopsy-defined geometry in an optical-thermal model. In R. R. Anderson, K. E. Bartels, L. S. Bass, & C. G. Garrett (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3245, pp. 322-333) https://doi.org/10.1117/12.312302

Laser treatment of port wine stains : Three-dimensional simulation using a biopsy-defined geometry in an optical-thermal model. / Pfefer, T. Joshua; Barton, Jennifer K; Smithies, Derek J.; Milner, Thomas E.; Nelson, J. Stuart; Van Gemert, Martin J C; Welch, A. J.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / R.R. Anderson; K.E. Bartels; L.S. Bass; C.G. Garrett. Vol. 3245 1997. p. 322-333.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pfefer, TJ, Barton, JK, Smithies, DJ, Milner, TE, Nelson, JS, Van Gemert, MJC & Welch, AJ 1997, Laser treatment of port wine stains: Three-dimensional simulation using a biopsy-defined geometry in an optical-thermal model. in RR Anderson, KE Bartels, LS Bass & CG Garrett (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 3245, pp. 322-333, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII, San Jose, CA, United States, 1/24/98. https://doi.org/10.1117/12.312302
Pfefer TJ, Barton JK, Smithies DJ, Milner TE, Nelson JS, Van Gemert MJC et al. Laser treatment of port wine stains: Three-dimensional simulation using a biopsy-defined geometry in an optical-thermal model. In Anderson RR, Bartels KE, Bass LS, Garrett CG, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3245. 1997. p. 322-333 https://doi.org/10.1117/12.312302
Pfefer, T. Joshua ; Barton, Jennifer K ; Smithies, Derek J. ; Milner, Thomas E. ; Nelson, J. Stuart ; Van Gemert, Martin J C ; Welch, A. J. / Laser treatment of port wine stains : Three-dimensional simulation using a biopsy-defined geometry in an optical-thermal model. Proceedings of SPIE - The International Society for Optical Engineering. editor / R.R. Anderson ; K.E. Bartels ; L.S. Bass ; C.G. Garrett. Vol. 3245 1997. pp. 322-333
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