LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice

Daniel Muller, Beverly H. Koller, J. Lindsay Whitton, Katherine E. LaPan, Kristen K. Brigman, Jeffrey A. Frelinger

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136 Scopus citations

Abstract

Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). β2-Microglobulin-deficient mice (ß 2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When β2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4 + CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.

Original languageEnglish (US)
Pages (from-to)1576-1578
Number of pages3
JournalScience
Volume255
Issue number5051
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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    Muller, D., Koller, B. H., Whitton, J. L., LaPan, K. E., Brigman, K. K., & Frelinger, J. A. (1992). LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice. Science, 255(5051), 1576-1578. https://doi.org/10.1126/science.1347959