LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice

Daniel Muller, Beverly H. Koller, J. Lindsay Whitton, Katherine E. Lapan, Kristen K. Brigman, Jeffrey A Frelinger

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). β2-Microglobulin-deficient mice (β2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When β2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4+ CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.

Original languageEnglish (US)
Pages (from-to)1576-1578
Number of pages3
JournalScience
Volume255
Issue number5051
StatePublished - Mar 20 1992
Externally publishedYes

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Lymphocytic choriomeningitis virus
Cytotoxic T-Lymphocytes
T-Lymphocytes
Major Histocompatibility Complex
Virus Diseases
Meningitis
Cause of Death
Infection
Proteins

ASJC Scopus subject areas

  • General

Cite this

Muller, D., Koller, B. H., Whitton, J. L., Lapan, K. E., Brigman, K. K., & Frelinger, J. A. (1992). LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice. Science, 255(5051), 1576-1578.

LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice. / Muller, Daniel; Koller, Beverly H.; Whitton, J. Lindsay; Lapan, Katherine E.; Brigman, Kristen K.; Frelinger, Jeffrey A.

In: Science, Vol. 255, No. 5051, 20.03.1992, p. 1576-1578.

Research output: Contribution to journalArticle

Muller, D, Koller, BH, Whitton, JL, Lapan, KE, Brigman, KK & Frelinger, JA 1992, 'LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice', Science, vol. 255, no. 5051, pp. 1576-1578.
Muller D, Koller BH, Whitton JL, Lapan KE, Brigman KK, Frelinger JA. LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice. Science. 1992 Mar 20;255(5051):1576-1578.
Muller, Daniel ; Koller, Beverly H. ; Whitton, J. Lindsay ; Lapan, Katherine E. ; Brigman, Kristen K. ; Frelinger, Jeffrey A. / LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice. In: Science. 1992 ; Vol. 255, No. 5051. pp. 1576-1578.
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