Left ventricular remodeling and ventricular arrhythmias after myocardial infarction

Martin St John Sutton, Douglas Lee, Jean Lucien Rouleau, Steven Goldman, Ted Plappert, Eugene Braunwald, Marc A. Pfeffer

Research output: Contribution to journalArticle

184 Scopus citations

Abstract

Background - The relation between left ventricular (LV) remodeling and ventricular arrhythmias after myocardial infarction is poorly documented. We investigated the relations between LV size, hypertrophy, and function and ventricular arrhythmias in 263 patients from the Survival and Ventricular Enlargement (SAVE) study, using quantitative 2D echocardiography and ambulatory ECG monitoring after myocardial infarction. Methods and Results - Transthoracic 2D echocardiograms and arrhythmia monitoring were performed at baseline (mean, 11 days) and 1 and 2 years after infarction. LV size, short-axis muscle (mass) area (LVMA), and function were quantified from 2D echocardiograms. The prevalence of ventricular tachycardia (VT) and frequent ventricular ectopy (premature ventricular contractions [PVCs] >10/h) was assessed from ambulatory ECG. VT and PVCs >10/h occurred in 20% and 29% of patients at baseline, in 22% and 35% at 1 year and 23% and 39% at 2 years, respectively. VT and PVCs >10/h at baseline and 1 and 2 years were significantly related to LV size, LVMA, and function. Furthermore, changes in LV size and function from baseline to 2 years predicted both VT and PVCs >10/h. The study was underpowered to detect treatment effect of ACE inhibitors and β-adrenergic receptor blockers but did not alter the relations between ventricular arrhythmias, LV size, and function. Conclusions - Quantitative echocardiographic assessment of LV size, LVMA, and function and changes in these measurements over time predict ventricular arrhythmias after infarction. Altered LV architecture and function during postinfarction LV remodeling provide an important substrate for triggering high-grade ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)2577-2582
Number of pages6
JournalCirculation
Volume107
Issue number20
StatePublished - May 27 2003

Keywords

  • Arrhythmia
  • Echocardiography
  • Myocardial infarction
  • Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    St John Sutton, M., Lee, D., Rouleau, J. L., Goldman, S., Plappert, T., Braunwald, E., & Pfeffer, M. A. (2003). Left ventricular remodeling and ventricular arrhythmias after myocardial infarction. Circulation, 107(20), 2577-2582.