Left ventricular shape index assessed by gated stress myocardial perfusion SPECT

Initial description of a new variable

Aiden Abidov, Piotr J. Slomka, Hidetaka Nishina, Sean W. Hayes, Xingping Kang, Shunichi Yoda, Ling De Yang, James Gerlach, Fatma Aboul-Enein, Ishac Cohen, John D. Friedman, Paul B. Kavanagh, Guido Germano, Daniel S. Berman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Ventricular remodeling is predictive of congestive heart failure (CHF). We aimed to automatically quantify a new myocardial shape variable on gated myocardial perfusion single photon emission computed tomography (SPECT) (MPS) and to evaluate the association of this new SPECT parameter with the risk of hospitalization for CHF. Methods and Results: A computer algorithm was used to measure the 3-dimensional (3D) left ventricular (LV) shape index (LVSI), derived as the ratio of maximum 3D short- and long-axis LV dimensions, for end systole and end diastole. LVSI normal limits were obtained from stress technetium 99m sestamibi MPS images of 186 patients (60% of whom were men) (control subjects) with a low likelihood of CAD (<5%). These limits were tested in a consecutive series of 93 inpatients (85% of whom were men) having MPS less than 1 week after hospitalization, of whom 25 were hospitalized for CHF exacerbation. Variables associated with CHF hospitalization were tested by receiver operating characteristic curve and multivariate logistic regression analyses. LVSI repeatability was assessed in 52 patients with ischemic cardiomyopathy who had sequential stress MPS within 60 days after the initial MPS without clinical events in the interval between MPS studies. Control subjects had lower end-systolic and end-diastolic LVSIs compared with patients with CHF and those without CHF (P < .001). Receiver operating characteristic curve areas for the prediction of hospitalization as a result of CHF were similar for LV ejection fraction and end-systolic LVSI. End-systolic and end-diastolic LVSIs were independent predictors of CHF hospitalization by multivariate analysis; however, end-systolic LVSI had the greatest added value among all tested variables. Repeatability was excellent for both end-systolic LVSI (R2 = 0.85, P < .0001) and end-diastolic LVSI (R2 = 0.82, P < .001). Conclusion: LVSI is a promising new 3D variable derived automatically from gated MPS providing highly repeatable ventricular shape assessment. Preliminary findings suggest that LVSI might have clinical implications in patients with CHF.

Original languageEnglish (US)
Pages (from-to)652-659
Number of pages8
JournalJournal of Nuclear Cardiology
Volume13
Issue number5
DOIs
StatePublished - Sep 2006
Externally publishedYes

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Single-Photon Emission-Computed Tomography
Heart Failure
Perfusion
Hospitalization
ROC Curve
Technetium Tc 99m Sestamibi
Ventricular Remodeling
Diastole
Systole
Cardiomyopathies
Stroke Volume
Inpatients
Multivariate Analysis
Logistic Models
Regression Analysis

Keywords

  • congestive heart failure
  • Diagnostic application
  • gated myocardial perfusion single photon emission computed tomography
  • left ventricular geometry

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Left ventricular shape index assessed by gated stress myocardial perfusion SPECT : Initial description of a new variable. / Abidov, Aiden; Slomka, Piotr J.; Nishina, Hidetaka; Hayes, Sean W.; Kang, Xingping; Yoda, Shunichi; Yang, Ling De; Gerlach, James; Aboul-Enein, Fatma; Cohen, Ishac; Friedman, John D.; Kavanagh, Paul B.; Germano, Guido; Berman, Daniel S.

In: Journal of Nuclear Cardiology, Vol. 13, No. 5, 09.2006, p. 652-659.

Research output: Contribution to journalArticle

Abidov, A, Slomka, PJ, Nishina, H, Hayes, SW, Kang, X, Yoda, S, Yang, LD, Gerlach, J, Aboul-Enein, F, Cohen, I, Friedman, JD, Kavanagh, PB, Germano, G & Berman, DS 2006, 'Left ventricular shape index assessed by gated stress myocardial perfusion SPECT: Initial description of a new variable', Journal of Nuclear Cardiology, vol. 13, no. 5, pp. 652-659. https://doi.org/10.1016/j.nuclcard.2006.05.020
Abidov, Aiden ; Slomka, Piotr J. ; Nishina, Hidetaka ; Hayes, Sean W. ; Kang, Xingping ; Yoda, Shunichi ; Yang, Ling De ; Gerlach, James ; Aboul-Enein, Fatma ; Cohen, Ishac ; Friedman, John D. ; Kavanagh, Paul B. ; Germano, Guido ; Berman, Daniel S. / Left ventricular shape index assessed by gated stress myocardial perfusion SPECT : Initial description of a new variable. In: Journal of Nuclear Cardiology. 2006 ; Vol. 13, No. 5. pp. 652-659.
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abstract = "Background: Ventricular remodeling is predictive of congestive heart failure (CHF). We aimed to automatically quantify a new myocardial shape variable on gated myocardial perfusion single photon emission computed tomography (SPECT) (MPS) and to evaluate the association of this new SPECT parameter with the risk of hospitalization for CHF. Methods and Results: A computer algorithm was used to measure the 3-dimensional (3D) left ventricular (LV) shape index (LVSI), derived as the ratio of maximum 3D short- and long-axis LV dimensions, for end systole and end diastole. LVSI normal limits were obtained from stress technetium 99m sestamibi MPS images of 186 patients (60{\%} of whom were men) (control subjects) with a low likelihood of CAD (<5{\%}). These limits were tested in a consecutive series of 93 inpatients (85{\%} of whom were men) having MPS less than 1 week after hospitalization, of whom 25 were hospitalized for CHF exacerbation. Variables associated with CHF hospitalization were tested by receiver operating characteristic curve and multivariate logistic regression analyses. LVSI repeatability was assessed in 52 patients with ischemic cardiomyopathy who had sequential stress MPS within 60 days after the initial MPS without clinical events in the interval between MPS studies. Control subjects had lower end-systolic and end-diastolic LVSIs compared with patients with CHF and those without CHF (P < .001). Receiver operating characteristic curve areas for the prediction of hospitalization as a result of CHF were similar for LV ejection fraction and end-systolic LVSI. End-systolic and end-diastolic LVSIs were independent predictors of CHF hospitalization by multivariate analysis; however, end-systolic LVSI had the greatest added value among all tested variables. Repeatability was excellent for both end-systolic LVSI (R2 = 0.85, P < .0001) and end-diastolic LVSI (R2 = 0.82, P < .001). Conclusion: LVSI is a promising new 3D variable derived automatically from gated MPS providing highly repeatable ventricular shape assessment. Preliminary findings suggest that LVSI might have clinical implications in patients with CHF.",
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T1 - Left ventricular shape index assessed by gated stress myocardial perfusion SPECT

T2 - Initial description of a new variable

AU - Abidov, Aiden

AU - Slomka, Piotr J.

AU - Nishina, Hidetaka

AU - Hayes, Sean W.

AU - Kang, Xingping

AU - Yoda, Shunichi

AU - Yang, Ling De

AU - Gerlach, James

AU - Aboul-Enein, Fatma

AU - Cohen, Ishac

AU - Friedman, John D.

AU - Kavanagh, Paul B.

AU - Germano, Guido

AU - Berman, Daniel S.

PY - 2006/9

Y1 - 2006/9

N2 - Background: Ventricular remodeling is predictive of congestive heart failure (CHF). We aimed to automatically quantify a new myocardial shape variable on gated myocardial perfusion single photon emission computed tomography (SPECT) (MPS) and to evaluate the association of this new SPECT parameter with the risk of hospitalization for CHF. Methods and Results: A computer algorithm was used to measure the 3-dimensional (3D) left ventricular (LV) shape index (LVSI), derived as the ratio of maximum 3D short- and long-axis LV dimensions, for end systole and end diastole. LVSI normal limits were obtained from stress technetium 99m sestamibi MPS images of 186 patients (60% of whom were men) (control subjects) with a low likelihood of CAD (<5%). These limits were tested in a consecutive series of 93 inpatients (85% of whom were men) having MPS less than 1 week after hospitalization, of whom 25 were hospitalized for CHF exacerbation. Variables associated with CHF hospitalization were tested by receiver operating characteristic curve and multivariate logistic regression analyses. LVSI repeatability was assessed in 52 patients with ischemic cardiomyopathy who had sequential stress MPS within 60 days after the initial MPS without clinical events in the interval between MPS studies. Control subjects had lower end-systolic and end-diastolic LVSIs compared with patients with CHF and those without CHF (P < .001). Receiver operating characteristic curve areas for the prediction of hospitalization as a result of CHF were similar for LV ejection fraction and end-systolic LVSI. End-systolic and end-diastolic LVSIs were independent predictors of CHF hospitalization by multivariate analysis; however, end-systolic LVSI had the greatest added value among all tested variables. Repeatability was excellent for both end-systolic LVSI (R2 = 0.85, P < .0001) and end-diastolic LVSI (R2 = 0.82, P < .001). Conclusion: LVSI is a promising new 3D variable derived automatically from gated MPS providing highly repeatable ventricular shape assessment. Preliminary findings suggest that LVSI might have clinical implications in patients with CHF.

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KW - Diagnostic application

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