Lens ion transport

From basic concepts to regulation of Na,K-ATPase activity

Nicholas A Delamere, Shigeo Tamiya

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In the late 1960s, studies by George Duncan explained many of the basic principles that underlie lens ion homeostasis. The experiments pointed to a permeability barrier close to the surface of the lens and illustrated the requirement for continuous Na,K-ATPase-mediated active sodium extrusion. Without active sodium extrusion, lens sodium and calcium content increases resulting in lens swelling and deterioration of transparency. Later, Duncan's laboratory discovered functional muscarinic and purinergic receptors at the surface of the lens. Recent studies using intact lens suggest purinergic receptors might be involved in short-term regulation of Na,K-ATPase in the epithelium. Purinergic receptor agonists ATP and UTP selectively activate certain Src family tyrosine kinases and stimulate Na,K-ATPase activity. This might represent part of a control mechanism capable of adjusting, perhaps fine tuning, lens ion transport machinery.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalExperimental Eye Research
Volume88
Issue number2
DOIs
StatePublished - Feb 2 2009

Fingerprint

Ion Transport
Lenses
Purinergic Receptors
Sodium
Purinergic Agonists
Uridine Triphosphate
src-Family Kinases
Muscarinic Receptors
sodium-translocating ATPase
Permeability
Homeostasis
Epithelium
Adenosine Triphosphate
Ions
Calcium

Keywords

  • ion transport
  • lens epithelium
  • Na,K-ATPase
  • purinergic receptor
  • tyrosine kinase

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Lens ion transport : From basic concepts to regulation of Na,K-ATPase activity. / Delamere, Nicholas A; Tamiya, Shigeo.

In: Experimental Eye Research, Vol. 88, No. 2, 02.02.2009, p. 140-143.

Research output: Contribution to journalArticle

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