Lens membrane properties following hydrogen peroxide exposure

Nicholas A Delamere, C. A. Paterson, S. Hensley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Rabbit lenses exposed to 0.5 mM hydrogen peroxide for 1 h and then incubated for an additional 19 h demonstrated small yet significant changes in electrolyte balance. Active cation pumping by the lens, as determined by 86Rb uptake studies, was partially impaired following 1 h hydrogen peroxide exposure; the cation pump further deteriorated during the subsequent 19-hour incubation. Passive membrane permeability of the lens, measured by 86Rb efflux, was elevated following 1 h hydrogen peroxide but no further increase in leakiness was observed during the subsequent 19-hour incubation. These findings suggest that even relatively brief exposure to oxidative damage initiates a chain of events from which the lens is unable to recover.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalOphthalmic Research
Volume20
Issue number3
StatePublished - 1988
Externally publishedYes

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Hydrogen Peroxide
Lenses
Membranes
Cation Transport Proteins
Water-Electrolyte Balance
Cations
Permeability
Rabbits

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lens membrane properties following hydrogen peroxide exposure. / Delamere, Nicholas A; Paterson, C. A.; Hensley, S.

In: Ophthalmic Research, Vol. 20, No. 3, 1988, p. 200-204.

Research output: Contribution to journalArticle

Delamere, NA, Paterson, CA & Hensley, S 1988, 'Lens membrane properties following hydrogen peroxide exposure', Ophthalmic Research, vol. 20, no. 3, pp. 200-204.
Delamere, Nicholas A ; Paterson, C. A. ; Hensley, S. / Lens membrane properties following hydrogen peroxide exposure. In: Ophthalmic Research. 1988 ; Vol. 20, No. 3. pp. 200-204.
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