Lens permeability changes associated with metabolic inhibition by iodoacetate

Nicholas A Delamere, C. A. Paterson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Sodium iodoacetate (IAA) at 10-3m was shown to cause a biphasic depolarization of the rabbit lens. The first portion of the depolarization was attributed to inhibition of the electrogenic sodium pump following depression of glycolysis. The larger second phase of lens depolarization, a transient increase both of lens conductance and 42K efflux rate, all indicate that IAA influences lens membrane permeability characteristics. After 100 min exposure to IAA, the lens potential stabilized at -39 mV, and lens conductance and 42K efflux rate stabilized at values close to the control values. These findings suggested that extended treatment with IAA increased the ratio of lens sodium to potassium permeability without increasing the overall leakiness of the lens.

Original languageEnglish (US)
Pages (from-to)797-802
Number of pages6
JournalExperimental Eye Research
Volume34
Issue number5
DOIs
Publication statusPublished - 1982
Externally publishedYes

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Keywords

  • calcium
  • electrolyte balance
  • membrane permeability
  • rabbit lens
  • sodium iodoacetate

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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