Leptin signaling protects the gut from Entamoeba histolytica infection

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The role of the adipose-derived hormone leptin, and leptin receptors, in signaling satiety to the central nervous system and regulating energy balance is well recognized. But leptin also acts on peripheral tissues such as skeletal muscles, adipose tissues, pancreas, liver, intestine and the immune system. The existence of different splice variants of leptin receptor and the numerous intracellular signaling pathways triggered by leptin make this a truly versatile system. Two recent studies explore the link between malnutrition, leptin signaling and susceptibility to amebic infection. These studies point to important and novel aspects of leptin signaling in maintaining gut homeostasis and warding off infections.

Original languageEnglish (US)
JournalGut Microbes
Volume3
Issue number1
StatePublished - Jan 2012

Fingerprint

Entamoeba histolytica
Leptin
Leptin Receptors
Infection
Malnutrition
Intestines
Adipose Tissue
Pancreas
Immune System
Skeletal Muscle
Homeostasis
Central Nervous System
Hormones
Muscles
Liver

Keywords

  • Diarrhea
  • Entamoeba histolytica
  • Infection
  • Leptin
  • Leptin receptor
  • Malnutrition

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

Cite this

Leptin signaling protects the gut from Entamoeba histolytica infection. / Vedantam, Gayatri; Viswanathan, Virinchipuram.

In: Gut Microbes, Vol. 3, No. 1, 01.2012.

Research output: Contribution to journalArticle

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