Leptin signaling protects the gut from Entamoeba histolytica infection

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The role of the adipose-derived hormone leptin, and leptin receptors, in signaling satiety to the central nervous system and regulating energy balance is well recognized. But leptin also acts on peripheral tissues such as skeletal muscles, adipose tissues, pancreas, liver, intestine and the immune system. The existence of different splice variants of leptin receptor and the numerous intracellular signaling pathways triggered by leptin make this a truly versatile system. Two recent studies explore the link between malnutrition, leptin signaling and susceptibility to amebic infection. These studies point to important and novel aspects of leptin signaling in maintaining gut homeostasis and warding off infections.

Original languageEnglish (US)
JournalGut microbes
Volume3
Issue number1
DOIs
StatePublished - 2012

Keywords

  • Diarrhea
  • Entamoeba histolytica
  • Infection
  • Leptin
  • Leptin receptor
  • Malnutrition

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

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