Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma

S. M. Lippman, T. M. Grogan, Catherine S Perry, C. F. Koopmann, E. P. Gall, D. S. Shimm, B. G. Durie

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Lethal midline granuloma (LMG), initially a clinical description, includes an uncommon group of disorders characterized by a relentless, destructive process involving the upper respiratory structures. Its etiology and pathogenesis are uncertain, probably varied, and the distinction between inflammatory and malignant processes is difficult despite extensive clinical and histopathologic evaluation. The need for new techniques for rapid diagnosis has important therapeutic implications. Using an extensive panel of T- and B-cell monoclonal antibodies the authors describe a patient with clinically and pathologically typical LMG demonstrating an 'activated' T-cell phenotype with a 'novel' pattern characteristic of peripheral T-cell lymphoma, strongly implying that some cases of LMG are more closely related to neoplastic T-cell lymphoproliferative disorders than to inflammatory conditions. Further studies using these immunotyping techniques may help clarify the pathogenesis of LMG, and may uncover specific diagnostic and prognostic phenotypic patterns.

Original languageEnglish (US)
Pages (from-to)936-939
Number of pages4
JournalCancer
Volume59
Issue number5
DOIs
StatePublished - 1987

Fingerprint

Lethal Midline Granuloma
Peripheral T-Cell Lymphoma
T-Lymphocytes
Phenotype
Lymphoproliferative Disorders
B-Lymphocytes
Monoclonal Antibodies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma. / Lippman, S. M.; Grogan, T. M.; Perry, Catherine S; Koopmann, C. F.; Gall, E. P.; Shimm, D. S.; Durie, B. G.

In: Cancer, Vol. 59, No. 5, 1987, p. 936-939.

Research output: Contribution to journalArticle

Lippman, S. M. ; Grogan, T. M. ; Perry, Catherine S ; Koopmann, C. F. ; Gall, E. P. ; Shimm, D. S. ; Durie, B. G. / Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma. In: Cancer. 1987 ; Vol. 59, No. 5. pp. 936-939.
@article{673268183cf34dbd9dae436edd60a1e5,
title = "Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma",
abstract = "Lethal midline granuloma (LMG), initially a clinical description, includes an uncommon group of disorders characterized by a relentless, destructive process involving the upper respiratory structures. Its etiology and pathogenesis are uncertain, probably varied, and the distinction between inflammatory and malignant processes is difficult despite extensive clinical and histopathologic evaluation. The need for new techniques for rapid diagnosis has important therapeutic implications. Using an extensive panel of T- and B-cell monoclonal antibodies the authors describe a patient with clinically and pathologically typical LMG demonstrating an 'activated' T-cell phenotype with a 'novel' pattern characteristic of peripheral T-cell lymphoma, strongly implying that some cases of LMG are more closely related to neoplastic T-cell lymphoproliferative disorders than to inflammatory conditions. Further studies using these immunotyping techniques may help clarify the pathogenesis of LMG, and may uncover specific diagnostic and prognostic phenotypic patterns.",
author = "Lippman, {S. M.} and Grogan, {T. M.} and Perry, {Catherine S} and Koopmann, {C. F.} and Gall, {E. P.} and Shimm, {D. S.} and Durie, {B. G.}",
year = "1987",
doi = "10.1002/1097-0142(19870301)59:5<936::AID-CNCR2820590514>3.0.CO;2-F",
language = "English (US)",
volume = "59",
pages = "936--939",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma

AU - Lippman, S. M.

AU - Grogan, T. M.

AU - Perry, Catherine S

AU - Koopmann, C. F.

AU - Gall, E. P.

AU - Shimm, D. S.

AU - Durie, B. G.

PY - 1987

Y1 - 1987

N2 - Lethal midline granuloma (LMG), initially a clinical description, includes an uncommon group of disorders characterized by a relentless, destructive process involving the upper respiratory structures. Its etiology and pathogenesis are uncertain, probably varied, and the distinction between inflammatory and malignant processes is difficult despite extensive clinical and histopathologic evaluation. The need for new techniques for rapid diagnosis has important therapeutic implications. Using an extensive panel of T- and B-cell monoclonal antibodies the authors describe a patient with clinically and pathologically typical LMG demonstrating an 'activated' T-cell phenotype with a 'novel' pattern characteristic of peripheral T-cell lymphoma, strongly implying that some cases of LMG are more closely related to neoplastic T-cell lymphoproliferative disorders than to inflammatory conditions. Further studies using these immunotyping techniques may help clarify the pathogenesis of LMG, and may uncover specific diagnostic and prognostic phenotypic patterns.

AB - Lethal midline granuloma (LMG), initially a clinical description, includes an uncommon group of disorders characterized by a relentless, destructive process involving the upper respiratory structures. Its etiology and pathogenesis are uncertain, probably varied, and the distinction between inflammatory and malignant processes is difficult despite extensive clinical and histopathologic evaluation. The need for new techniques for rapid diagnosis has important therapeutic implications. Using an extensive panel of T- and B-cell monoclonal antibodies the authors describe a patient with clinically and pathologically typical LMG demonstrating an 'activated' T-cell phenotype with a 'novel' pattern characteristic of peripheral T-cell lymphoma, strongly implying that some cases of LMG are more closely related to neoplastic T-cell lymphoproliferative disorders than to inflammatory conditions. Further studies using these immunotyping techniques may help clarify the pathogenesis of LMG, and may uncover specific diagnostic and prognostic phenotypic patterns.

UR - http://www.scopus.com/inward/record.url?scp=0023116924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023116924&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19870301)59:5<936::AID-CNCR2820590514>3.0.CO;2-F

DO - 10.1002/1097-0142(19870301)59:5<936::AID-CNCR2820590514>3.0.CO;2-F

M3 - Article

C2 - 3493060

AN - SCOPUS:0023116924

VL - 59

SP - 936

EP - 939

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 5

ER -