Leukocyte filtration in lung transplantation

Mark Kurusz, John D. Roach, Roger A. Vertrees, Mark K. Girouard, Scott D Lick

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Controlled reperfusion of the transplanted lung has been used in nine consecutive patients to decrease manifestations of lung reperfusion injury. An extracorporeal circuit containing a roller pump, heat exchanger and leukodepleting filter is primed with substrate-enhanced reperfusion solution mixed with approximately 2000 ml of the patient's blood. This solution is slowly recirculated to remove leukocytes prior to reperfusion. When the pulmonary anastomoses are completed, the pulmonary artery is cannulated through the untied anastomosis using a catheter containing a pressure lumen for measurement of infusion pressure. An atrial clamp is left in place on the patient's native atrial cuff to decrease the risk of systemic air embolism during the brief period of reperfusion from the extracorporeal reservoir. During reperfusion, the water bath to the heat exchanger is kept at 35°C and the flow rate for reperfusion solution is between 150 and 200 ml/min, keeping the pulmonary artery pressure <14 mmHg. Eight of nine patients were ventilated on 40% inspired oxygen within a few hours of operation and 7/9 were extubated on or before postoperative day 1. Six of nine patients are long-term survivors.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalPerfusion
Volume17
Issue numberSUPPL.
StatePublished - 2002
Externally publishedYes

Fingerprint

hours of operation
Lung Transplantation
heat pump
Reperfusion
heat
Leukocytes
air
water
Heat exchangers
Catheters
Clamping devices
Pressure
Pulmonary Artery
Blood
Hot Temperature
Flow rate
Pumps
Air Embolism
Lung
Oxygen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kurusz, M., Roach, J. D., Vertrees, R. A., Girouard, M. K., & Lick, S. D. (2002). Leukocyte filtration in lung transplantation. Perfusion, 17(SUPPL.), 63-67.

Leukocyte filtration in lung transplantation. / Kurusz, Mark; Roach, John D.; Vertrees, Roger A.; Girouard, Mark K.; Lick, Scott D.

In: Perfusion, Vol. 17, No. SUPPL., 2002, p. 63-67.

Research output: Contribution to journalArticle

Kurusz, M, Roach, JD, Vertrees, RA, Girouard, MK & Lick, SD 2002, 'Leukocyte filtration in lung transplantation', Perfusion, vol. 17, no. SUPPL., pp. 63-67.
Kurusz M, Roach JD, Vertrees RA, Girouard MK, Lick SD. Leukocyte filtration in lung transplantation. Perfusion. 2002;17(SUPPL.):63-67.
Kurusz, Mark ; Roach, John D. ; Vertrees, Roger A. ; Girouard, Mark K. ; Lick, Scott D. / Leukocyte filtration in lung transplantation. In: Perfusion. 2002 ; Vol. 17, No. SUPPL. pp. 63-67.
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