Leveraging population admixture to characterize the heritability of complex traits

Noah Zaitlen, Bogdan Pasaniuc, Sriram Sankararaman, Gaurav Bhatia, Jianqi Zhang, Alexander Gusev, Taylor Young, Arti Tandon, Samuela Pollack, Bjarni J. Vilhjálmsson, Themistocles L. Assimes, Sonja I. Berndt, William J. Blot, Stephen Chanock, Nora Franceschini, Phyllis G. Goodman, Jing He, Anselm J M Hennis, Ann Hsing, Sue A. InglesWilliam Isaacs, Rick A Kittles, Eric A. Klein, Leslie A. Lange, Barbara Nemesure, Nick Patterson, David Reich, Benjamin A. Rybicki, Janet L. Stanford, Victoria L. Stevens, Sara S. Strom, Eric A. Whitsel, John S. Witte, Jianfeng Xu, Christopher Haiman, James G. Wilson, Charles Kooperberg, Daniel Stram, Alex P. Reiner, Hua Tang, Alkes L. Price

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Despite recent progress on estimating the heritability explained by genotyped SNPs (h 2 g), a large gap between h 2 g and estimates of total narrow-sense heritability (h 2) remains. Explanations for this gap include rare variants or upward bias in family-based estimates of h 2 due to shared environment or epistasis. We estimate h 2 from unrelated individuals in admixed populations by first estimating the heritability explained by local ancestry (h 2 3). We show that h 2 3 = 2F STC (1 ')h 2, where F STC measures frequency differences between populations at causal loci and is the genome-wide ancestry proportion. Our approach is not susceptible to biases caused by epistasis or shared environment. We applied this approach to the analysis of 13 phenotypes in 21,497 African-American individuals from 3 cohorts. For height and body mass index (BMI), we obtained h 2 estimates of 0.55 ± 0.09 and 0.23 ± 0.06, respectively, which are larger than estimates of h 2 g in these and other data but smaller than family-based estimates of h 2.

Original languageEnglish (US)
Pages (from-to)1356-1362
Number of pages7
JournalNature Genetics
Volume46
Issue number12
DOIs
StatePublished - Dec 11 2014
Externally publishedYes

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African Americans
Population
Single Nucleotide Polymorphism
Body Mass Index
Genome
Phenotype

ASJC Scopus subject areas

  • Genetics
  • Medicine(all)

Cite this

Zaitlen, N., Pasaniuc, B., Sankararaman, S., Bhatia, G., Zhang, J., Gusev, A., ... Price, A. L. (2014). Leveraging population admixture to characterize the heritability of complex traits. Nature Genetics, 46(12), 1356-1362. https://doi.org/10.1038/ng.3139

Leveraging population admixture to characterize the heritability of complex traits. / Zaitlen, Noah; Pasaniuc, Bogdan; Sankararaman, Sriram; Bhatia, Gaurav; Zhang, Jianqi; Gusev, Alexander; Young, Taylor; Tandon, Arti; Pollack, Samuela; Vilhjálmsson, Bjarni J.; Assimes, Themistocles L.; Berndt, Sonja I.; Blot, William J.; Chanock, Stephen; Franceschini, Nora; Goodman, Phyllis G.; He, Jing; Hennis, Anselm J M; Hsing, Ann; Ingles, Sue A.; Isaacs, William; Kittles, Rick A; Klein, Eric A.; Lange, Leslie A.; Nemesure, Barbara; Patterson, Nick; Reich, David; Rybicki, Benjamin A.; Stanford, Janet L.; Stevens, Victoria L.; Strom, Sara S.; Whitsel, Eric A.; Witte, John S.; Xu, Jianfeng; Haiman, Christopher; Wilson, James G.; Kooperberg, Charles; Stram, Daniel; Reiner, Alex P.; Tang, Hua; Price, Alkes L.

In: Nature Genetics, Vol. 46, No. 12, 11.12.2014, p. 1356-1362.

Research output: Contribution to journalArticle

Zaitlen, N, Pasaniuc, B, Sankararaman, S, Bhatia, G, Zhang, J, Gusev, A, Young, T, Tandon, A, Pollack, S, Vilhjálmsson, BJ, Assimes, TL, Berndt, SI, Blot, WJ, Chanock, S, Franceschini, N, Goodman, PG, He, J, Hennis, AJM, Hsing, A, Ingles, SA, Isaacs, W, Kittles, RA, Klein, EA, Lange, LA, Nemesure, B, Patterson, N, Reich, D, Rybicki, BA, Stanford, JL, Stevens, VL, Strom, SS, Whitsel, EA, Witte, JS, Xu, J, Haiman, C, Wilson, JG, Kooperberg, C, Stram, D, Reiner, AP, Tang, H & Price, AL 2014, 'Leveraging population admixture to characterize the heritability of complex traits', Nature Genetics, vol. 46, no. 12, pp. 1356-1362. https://doi.org/10.1038/ng.3139
Zaitlen N, Pasaniuc B, Sankararaman S, Bhatia G, Zhang J, Gusev A et al. Leveraging population admixture to characterize the heritability of complex traits. Nature Genetics. 2014 Dec 11;46(12):1356-1362. https://doi.org/10.1038/ng.3139
Zaitlen, Noah ; Pasaniuc, Bogdan ; Sankararaman, Sriram ; Bhatia, Gaurav ; Zhang, Jianqi ; Gusev, Alexander ; Young, Taylor ; Tandon, Arti ; Pollack, Samuela ; Vilhjálmsson, Bjarni J. ; Assimes, Themistocles L. ; Berndt, Sonja I. ; Blot, William J. ; Chanock, Stephen ; Franceschini, Nora ; Goodman, Phyllis G. ; He, Jing ; Hennis, Anselm J M ; Hsing, Ann ; Ingles, Sue A. ; Isaacs, William ; Kittles, Rick A ; Klein, Eric A. ; Lange, Leslie A. ; Nemesure, Barbara ; Patterson, Nick ; Reich, David ; Rybicki, Benjamin A. ; Stanford, Janet L. ; Stevens, Victoria L. ; Strom, Sara S. ; Whitsel, Eric A. ; Witte, John S. ; Xu, Jianfeng ; Haiman, Christopher ; Wilson, James G. ; Kooperberg, Charles ; Stram, Daniel ; Reiner, Alex P. ; Tang, Hua ; Price, Alkes L. / Leveraging population admixture to characterize the heritability of complex traits. In: Nature Genetics. 2014 ; Vol. 46, No. 12. pp. 1356-1362.
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AU - Pasaniuc, Bogdan

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AU - Zhang, Jianqi

AU - Gusev, Alexander

AU - Young, Taylor

AU - Tandon, Arti

AU - Pollack, Samuela

AU - Vilhjálmsson, Bjarni J.

AU - Assimes, Themistocles L.

AU - Berndt, Sonja I.

AU - Blot, William J.

AU - Chanock, Stephen

AU - Franceschini, Nora

AU - Goodman, Phyllis G.

AU - He, Jing

AU - Hennis, Anselm J M

AU - Hsing, Ann

AU - Ingles, Sue A.

AU - Isaacs, William

AU - Kittles, Rick A

AU - Klein, Eric A.

AU - Lange, Leslie A.

AU - Nemesure, Barbara

AU - Patterson, Nick

AU - Reich, David

AU - Rybicki, Benjamin A.

AU - Stanford, Janet L.

AU - Stevens, Victoria L.

AU - Strom, Sara S.

AU - Whitsel, Eric A.

AU - Witte, John S.

AU - Xu, Jianfeng

AU - Haiman, Christopher

AU - Wilson, James G.

AU - Kooperberg, Charles

AU - Stram, Daniel

AU - Reiner, Alex P.

AU - Tang, Hua

AU - Price, Alkes L.

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