Lewis acid promoted conjugate addition of vinylmagnesium bromide to chiral α,β-unsaturated N-acyl oxazolidinones

Yinglin Han, Victor J Hruby

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27 Scopus citations

Abstract

Lewis acid promoted conjugated additions of vinylmagnesium bromide to chiral α,β-unsaturated N-acyl oxazolidinones are described. A series of enatiomerically pure β-branched 4-pentenoic acid derivatives have been synthesized with high diastereoselectivity.

Original languageEnglish (US)
Pages (from-to)7317-7320
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number42
DOIs
Publication statusPublished - Oct 20 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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