Library-based scatter correction for dedicated cone beam breast CT: A feasibility study

Linxi Shi, Srinivasan Vedantham, Andrew Karellas, Lei Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Purpose: Scatter errors are detrimental to cone-beam breast CT (CBBCT) accuracy and obscure the visibility of calcifications and soft-tissue lesions. In this work, we propose practical yet effective scatter correction for CBBCT using a library-based method and investigate its feasibility via small-group patient studies. Method: Based on a simplified breast model with varying breast sizes, we generate a scatter library using Monte-Carlo (MC) simulation. Breasts are approximated as semi-ellipsoids with homogeneous glandular/adipose tissue mixture. On each patient CBBCT projection dataset, an initial estimate of scatter distribution is selected from the pre-computed scatter library by measuring the corresponding breast size on raw projections and the glandular fraction on a first-pass CBBCT reconstruction. Then the selected scatter distribution is modified by estimating the spatial translation of the breast between MC simulation and the clinical scan. Scatter correction is finally performed by subtracting the estimated scatter from raw projections. Results: On two sets of clinical patient CBBCT data with different breast sizes, the proposed method effectively reduces cupping artifact and improves the image contrast by an average factor of 2, with an efficient processing time of 200ms per conebeam projection. Conclusion: Compared with existing scatter correction approaches on CBBCT, the proposed library-based method is clinically advantageous in that it requires no additional scans or hardware modifications. As the MC simulations are pre-computed, our method achieves a high computational efficiency on each patient dataset. The library-based method has shown great promise as a practical tool for effective scatter correction on clinical CBBCT.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016
Subtitle of host publicationPhysics of Medical Imaging
EditorsDespina Kontos, Joseph Y. Lo, Thomas G. Flohr
PublisherSPIE
ISBN (Electronic)9781510600188
DOIs
StatePublished - Jan 1 2016
Externally publishedYes
EventMedical Imaging 2016: Physics of Medical Imaging - San Diego, United States
Duration: Feb 28 2016Mar 2 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9783
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2016: Physics of Medical Imaging
CountryUnited States
CitySan Diego
Period2/28/163/2/16

Keywords

  • cone-beam breast CT
  • Monte Carlo simulation
  • scatter correction
  • scatter library

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Shi, L., Vedantham, S., Karellas, A., & Zhu, L. (2016). Library-based scatter correction for dedicated cone beam breast CT: A feasibility study. In D. Kontos, J. Y. Lo, & T. G. Flohr (Eds.), Medical Imaging 2016: Physics of Medical Imaging [978330] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9783). SPIE. https://doi.org/10.1117/12.2217327