Ligand-controlled self-assembly of polynuclear lanthanide-oxo/hydroxo complexes: From synthetic serendipity to rational supramolecular design

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Abstract

Lanthanide ions and complexes occupy a special position in developing synthetic nucleases capable of catalyzing the hydrolytic cleavage of RNA or DNA. Stimulated by a number of serendipitous lanthanide complexes that feature the common active-site structure of dinuclear metallo-phosphodiesterases, rational design and synthesis of polynuclear lanthanide-hydroxo species via ligand-controlled hydrolysis of the lanthanide ions were attempted. The efforts yielded a series of highly sophisticated yet structurally well-defined lanthanide-hydroxo complexes. These materials are potentially applicable to the study of biomimetic catalysis of phosphate diester cleavage. Research highlights are described in this Feature Article.

Original languageEnglish (US)
Pages (from-to)2521-2529
Number of pages9
JournalChemical Communications
Issue number24
StatePublished - Dec 21 2001

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Lanthanoid Series Elements
Rare earth elements
Self assembly
Ligands
Ions
Phosphoric Diester Hydrolases
Biomimetics
RNA
Catalysis
Hydrolysis
Phosphates
DNA

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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