Light-induced content release from plasmon-resonant liposomes

Timothy S. Troutman, Sarah J. Leung, Marek Romanowski

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

A study was conducted to demonstrate light-induced content release from plasmon-resnant liposomes. The study also involved encapsulation of a model compound in thermosenstive liposomes, which then coated with gold to form plasmon-resonant shells with optical resonance tunable in the near-infrared range. It was observed that when exposed to 1064 nm laser light, these liposomes released their content in a spectrally-dependent manner. It was also found that the plasmon-resonant coating deposited on the surface of temperature-sensitive liposomes enhanced light-controlled release of payloads through the photothermal conversion of energy of absorbed light. The reduction of gold to the surface of the liposomes produced a final structure of 127 nm in diameter. This method could be used for application in complex diagnostic tests and therapeutic intervention requiring sequential delivery of agents.

Original languageEnglish (US)
Pages (from-to)2334-2338
Number of pages5
JournalAdvanced Materials
Volume21
Issue number22
DOIs
StatePublished - Jun 12 2009

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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