Light-induced release from gold-coated liposomes

S. Leung, M. Romanowski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We have computationally refined an experimental system with the potential for delivery and localized release of an encapsulated agent with high spatial and temporal resolution. We recently presented liposome-supported plasmon resonant gold nanoshells; in this composite structure, the liposome allows for the encapsulation of substances and the plasmon resonant structure facilitates rapid release of encapsulated contents upon laser light illumination. Using computational modeling, we now demonstrate that these liposome-supported nanoshells induce less local heating than solid gold spheres under optical trapping conditions, reducing their likelihood of damaging biological tissues used with this manipulation mechanism. We then present a general scheme for trapping of and localized release from gold-coated liposomes to enable accurate perturbation of cellular functions in response to released compounds, with possible applications in signalling pathways and drug discovery.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages295-297
Number of pages3
StatePublished - Nov 23 2011
EventNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: Jun 13 2011Jun 16 2011

Publication series

NameTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume3

Other

OtherNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
CountryUnited States
CityBoston, MA
Period6/13/116/16/11

Keywords

  • Controlled release
  • Liposome
  • Nanoparticle
  • Optical trapping
  • Plasmon resonance

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Leung, S., & Romanowski, M. (2011). Light-induced release from gold-coated liposomes. In Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 (pp. 295-297). (Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011; Vol. 3).