Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

A. A.Leslie Gunatilaka, Vanderlan Da S. Bolzani, Ermias Dagne, Glenn A. Hofmann, Randall K. Johnson, Francis L. McCabe, Michael R. Mattern, David G.I. Kingston

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalJournal Of Natural Products
Volume61
Issue number2
DOIs
StatePublished - Feb 1 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Gunatilaka, A. A. L., Bolzani, V. D. S., Dagne, E., Hofmann, G. A., Johnson, R. K., McCabe, F. L., Mattern, M. R., & Kingston, D. G. I. (1998). Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica. Journal Of Natural Products, 61(2), 179-184. https://doi.org/10.1021/np9701687