Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series

Francis J. McMahon, Penelope J. Hopkins, Jianfeng Xu, Melvin G. McInnis, Sarah Shaw, Lon Cardon, Sylvia G. Simpson, Dean F. MacKinnon, O. Colin Stine, Robin Sherrington, Deborah A. Meyers, J. Raymond DePaulo

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

Several groups have reported evidence suggesting linkage of bipolar affective disorder (BPAD) to chromosome 18. We have reported data from 28 pedigrees that showed linkage to marker loci on 18p and to loci 40 cM distant on 18q. Most of the linkage evidence derived from families with affected phenotypes in only the paternal lineage and from marker alleles transmitted on the paternal chromosome. We now report results from a series of 30 new pedigrees (259 individuals) genotyped for 13 polymorphic markers spanning chromosome 18. Subjects were interviewed by a psychiatrist and were diagnosed by highly reliable methods. Genotypes were generated with automated technology and were scored blind to phenotype. Affected sib pairs showed excess allele sharing at the 18q markers D18S541 and D18S38. A parent-of- origin effect was observed, but it was not consistently paternal. No robust evidence of linkage was detected for markers elsewhere on chromosome 18. Multipoint nonparametric linkage analysis in the new sample combined with the original sample of families supports linkage on chromosome 18q, but the susceptibility gene is not well localized.

Original languageEnglish (US)
Pages (from-to)1397-1404
Number of pages8
JournalAmerican Journal of Human Genetics
Volume61
Issue number6
DOIs
StatePublished - Dec 1997
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series'. Together they form a unique fingerprint.

Cite this