Linkage of circulating eosinophils to markers on chromosome 5q

Fernando Martinez, Susan Solomon, Catharine J. Holberg, Penelope E. Graves, Mauro Baldini, Robert P. Erickson

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Although peripheral blood eosinophilia is strongly associated with the risk of developing asthma, genetic determinants of eosinophilia have not been extensively studied. We used sib-pair analysis to assess linkage of circulating eosinophils (as a percent of total white blood cells [WBC]) to nine markers located in chromosome 5q31-33. The study was divided into two phases. Of 246 sib pairs available for the first phase, 35 were classified as low concordant (LC) (both sibs had ≤ 2% circulating eosinophils), 18 were defined as high concordant (HC) (both sibs had 5% or more circulating eosinophils), and 26 were defined as discordant (one sib had ≤ 2% and the other sib had 5% or more circulating eosinophils). Significant evidence for linkage among low concordant sib pairs was found for several markers in the region under study, with a peak for marker D5S500 (proportion of alleles shared identical by descent [ibd] = 0.68 ± 0.05 [mean ± SE], p = 0.0004). A cross-validating study was done in which an additional 19 sib pairs that were low concordant for circulating eosinophils were studied. Evidence for linkage was also observed in this subset. Results were independent of current wheezing, total serum IgE levels, and other potential confounders. A multipoint analysis done for all low-concordant sib pairs available showed that the maximal logarithm of the odds favoring genetic linkage (LOD) score (2.4, p = 0.0004) was observed in correspondence with marker D5S658. We conclude that a locus or loci may be present in chromosome 5q31-33 that controls for circulating eosinophils as a proportion of total WBC.

Original languageEnglish (US)
Pages (from-to)1739-1744
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume158
Issue number6
StatePublished - 1998

Fingerprint

Genetic Markers
Eosinophils
Eosinophilia
Leukocytes
Chromosomes
Genetic Linkage
Respiratory Sounds
Immunoglobulin E
Asthma
Alleles
Serum

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Martinez, F., Solomon, S., Holberg, C. J., Graves, P. E., Baldini, M., & Erickson, R. P. (1998). Linkage of circulating eosinophils to markers on chromosome 5q. American Journal of Respiratory and Critical Care Medicine, 158(6), 1739-1744.

Linkage of circulating eosinophils to markers on chromosome 5q. / Martinez, Fernando; Solomon, Susan; Holberg, Catharine J.; Graves, Penelope E.; Baldini, Mauro; Erickson, Robert P.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 158, No. 6, 1998, p. 1739-1744.

Research output: Contribution to journalArticle

Martinez, F, Solomon, S, Holberg, CJ, Graves, PE, Baldini, M & Erickson, RP 1998, 'Linkage of circulating eosinophils to markers on chromosome 5q', American Journal of Respiratory and Critical Care Medicine, vol. 158, no. 6, pp. 1739-1744.
Martinez, Fernando ; Solomon, Susan ; Holberg, Catharine J. ; Graves, Penelope E. ; Baldini, Mauro ; Erickson, Robert P. / Linkage of circulating eosinophils to markers on chromosome 5q. In: American Journal of Respiratory and Critical Care Medicine. 1998 ; Vol. 158, No. 6. pp. 1739-1744.
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