Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: A preliminary study

G. Lopez-Berestein, V. Fainstein, R. Hopfer, K. Mehta, M. P. Sullivan, M. Keating, M. G. Rosenblum, R. Mehta, M. Luna, Evan M Hersh

Research output: Contribution to journalArticle

341 Citations (Scopus)

Abstract

Twelve patients with hematologic malignancies complicated by fungal infections were treated with liposomal amphotericin B (L-AmpB). Nine patients were granulocytopenic; the three additional patients with normal granulocyte counts were immunosuppressed. All patients had biopsy findings or cultural evidence of the progression of their fungal infection while being treated with conventional amphotericin B. Doses of 0.8-1.0 mg/kg of L-AmpB were administered intravenously every 24-72 hr. Three patients had a complete remission, five had a partial remission, and four showed no improvements. A total of 161 doses of L-AmpB were administered. Fever and chills occurred on seven occasions. No hematologic or blood chemistry abnormalities related to L-AmpB treatment were observed.

Original languageEnglish (US)
Pages (from-to)704-710
Number of pages7
JournalJournal of Infectious Diseases
Volume151
Issue number4
StatePublished - 1985
Externally publishedYes

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Mycoses
Neoplasms
Therapeutics
Chills
Amphotericin B
Hematologic Neoplasms
Granulocytes
Fever
liposomal amphotericin B
Biopsy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Lopez-Berestein, G., Fainstein, V., Hopfer, R., Mehta, K., Sullivan, M. P., Keating, M., ... Hersh, E. M. (1985). Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: A preliminary study. Journal of Infectious Diseases, 151(4), 704-710.

Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer : A preliminary study. / Lopez-Berestein, G.; Fainstein, V.; Hopfer, R.; Mehta, K.; Sullivan, M. P.; Keating, M.; Rosenblum, M. G.; Mehta, R.; Luna, M.; Hersh, Evan M.

In: Journal of Infectious Diseases, Vol. 151, No. 4, 1985, p. 704-710.

Research output: Contribution to journalArticle

Lopez-Berestein, G, Fainstein, V, Hopfer, R, Mehta, K, Sullivan, MP, Keating, M, Rosenblum, MG, Mehta, R, Luna, M & Hersh, EM 1985, 'Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: A preliminary study', Journal of Infectious Diseases, vol. 151, no. 4, pp. 704-710.
Lopez-Berestein G, Fainstein V, Hopfer R, Mehta K, Sullivan MP, Keating M et al. Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: A preliminary study. Journal of Infectious Diseases. 1985;151(4):704-710.
Lopez-Berestein, G. ; Fainstein, V. ; Hopfer, R. ; Mehta, K. ; Sullivan, M. P. ; Keating, M. ; Rosenblum, M. G. ; Mehta, R. ; Luna, M. ; Hersh, Evan M. / Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer : A preliminary study. In: Journal of Infectious Diseases. 1985 ; Vol. 151, No. 4. pp. 704-710.
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