List-mode MLEM image reconstruction from 3D ML position estimates

Luca Caucci, William C J Hunter, Lars R Furenlid, Harrison H Barrett

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Current thick detectors used in medical imaging allow recording many attributes, such as the 3D location of interaction within the scintillation crystal and the amount of energy deposited. An efficient way of dealing with these data is by storing them in list-mode (LM). To reconstruct the data, maximum-likelihood expectation-maximization (MLEM) is efficiently applied to the list-mode data, resulting in the list-mode maximum-likelihood expectation-maximization (LMMLEM) reconstruction algorithm. In this work, we consider a PET system consisting of two thick detectors facing each other. PMT outputs are collected for each coincidence event and are used to perform 3D maximum-likelihood (ML) position estimation of location of interaction. The mathematical properties of the ML estimation allow accurate modeling of the detector blur and provide a theoretical framework for the subsequent estimation step, namely the LMM-LEM reconstruction. Indeed, a rigorous statistical model for the detector output can be obtained from calibration data and used in the calculation of the conditional probability density functions for the interaction location estimates. Our implementation of the 3D ML position estimation takes advantage of graphics processing unit (GPU) hardware and permits accurate real-time estimates of position of interaction. The LMMLEM algorithm is then applied to the list of position estimates, and the 3D radiotracer distribution is reconstructed on a voxel grid.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages2643-2647
Number of pages5
DOIs
StatePublished - 2010
Event2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States
Duration: Oct 30 2010Nov 6 2010

Other

Other2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
CountryUnited States
CityKnoxville, TN
Period10/30/1011/6/10

Fingerprint

Likelihood Functions
Computer-Assisted Image Processing
image reconstruction
lists
Statistical Models
Diagnostic Imaging
estimates
Calibration
detectors
Lunar Module
interactions
output
probability density functions
scintillation
hardware
recording
grids

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Caucci, L., Hunter, W. C. J., Furenlid, L. R., & Barrett, H. H. (2010). List-mode MLEM image reconstruction from 3D ML position estimates. In IEEE Nuclear Science Symposium Conference Record (pp. 2643-2647). [5874269] https://doi.org/10.1109/NSSMIC.2010.5874269

List-mode MLEM image reconstruction from 3D ML position estimates. / Caucci, Luca; Hunter, William C J; Furenlid, Lars R; Barrett, Harrison H.

IEEE Nuclear Science Symposium Conference Record. 2010. p. 2643-2647 5874269.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Caucci, L, Hunter, WCJ, Furenlid, LR & Barrett, HH 2010, List-mode MLEM image reconstruction from 3D ML position estimates. in IEEE Nuclear Science Symposium Conference Record., 5874269, pp. 2643-2647, 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010, Knoxville, TN, United States, 10/30/10. https://doi.org/10.1109/NSSMIC.2010.5874269
Caucci L, Hunter WCJ, Furenlid LR, Barrett HH. List-mode MLEM image reconstruction from 3D ML position estimates. In IEEE Nuclear Science Symposium Conference Record. 2010. p. 2643-2647. 5874269 https://doi.org/10.1109/NSSMIC.2010.5874269
Caucci, Luca ; Hunter, William C J ; Furenlid, Lars R ; Barrett, Harrison H. / List-mode MLEM image reconstruction from 3D ML position estimates. IEEE Nuclear Science Symposium Conference Record. 2010. pp. 2643-2647
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