Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice

Robert N. Fontaine, Ruanna E. Gossett, Friedhelm Schroeder, Barbara A. O'Toole, Thomas Doetschman, Ann B. Kier

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The effect of transforming growth factor beta-1 (TGFβ1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGFβ1-deficient mice. Homozygous TGFβ1-deficient 129 x CF-1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid binding protein (L-FABP) when compared to control mice. The decrease in L-FABP expression was not due to multifocal inflammatory syndrome since homozygous TGFβ1-deficient/immunodeficient C3H mice on a SCID background had 36% lower liver L-FABP than controls. This effect was developmentally related and specific to liver, but not the proximal intestine, where L-FABP is also expressed. Finally, the proximal intestine also expresses intestinal-FABP (I-FABP) which decreased 3-fold in the TGFβ1-deficient/immunodeficient C3H mice only. Thus, TGFβ1 appears to regulate the expression of L-FABP and I-FABP in the liver and the proximal intestine, respectively.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalMolecular and Cellular Biochemistry
Volume159
Issue number2
DOIs
StatePublished - Aug 15 1996
Externally publishedYes

Keywords

  • Fatty acid binding protein
  • Growth factor
  • Intestine
  • Liver
  • TGFβ1

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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