Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice

Robert N. Fontaine, Ruanna E. Gossett, Friedhelm Schroeder, Barbara A. O'Toole, Thomas C Doetschman, Ann B. Kier

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of transforming growth factor beta-1 (TGFβ1) expression on fatty acid binding proteins was examined in control and two strains of gene targeted TGFβ1-deficient mice. Homozygous TGFβ1-deficient 129 x CF-1, expressing multifocal inflammatory syndrome, had 25% less liver fatty acid binding protein (L-FABP) when compared to control mice. The decrease in L-FABP expression was not due to multifocal inflammatory syndrome since homozygous TGFβ1-deficient/immunodeficient C3H mice on a SCID background had 36% lower liver L-FABP than controls. This effect was developmentally related and specific to liver, but not the proximal intestine, where L-FABP is also expressed. Finally, the proximal intestine also expresses intestinal-FABP (I-FABP) which decreased 3-fold in the TGFβ1-deficient/immunodeficient C3H mice only. Thus, TGFβ1 appears to regulate the expression of L-FABP and I-FABP in the liver and the proximal intestine, respectively.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalMolecular and Cellular Biochemistry
Volume159
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

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Fatty Acid-Binding Proteins
Transforming Growth Factor beta
Genes
Liver
Intestines
Inbred C3H Mouse

Keywords

  • Fatty acid binding protein
  • Growth factor
  • Intestine
  • Liver
  • TGFβ1

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice. / Fontaine, Robert N.; Gossett, Ruanna E.; Schroeder, Friedhelm; O'Toole, Barbara A.; Doetschman, Thomas C; Kier, Ann B.

In: Molecular and Cellular Biochemistry, Vol. 159, No. 2, 1996, p. 149-153.

Research output: Contribution to journalArticle

Fontaine, Robert N. ; Gossett, Ruanna E. ; Schroeder, Friedhelm ; O'Toole, Barbara A. ; Doetschman, Thomas C ; Kier, Ann B. / Liver and intestinal fatty acid binding proteins in control and TGFβ1 gene targeted deficient mice. In: Molecular and Cellular Biochemistry. 1996 ; Vol. 159, No. 2. pp. 149-153.
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