Living related liver transplantation in infants and children: Report of anesthetic care and early postoperative morbidity and mortality

Claudia Wagner, David S. Beebe, Richard J. Carr, Vijaya Komanduri, Abhinav Humar, Rainer W G Gruessner, Kumar G. Belani

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Study Objective: To determine those infants at high risk for perioperative complications and mortality following living, related liver transplantation. Design: Retrospective chart review. Setting: Large metropolitan teaching hospital. Measurements and Main Results: The charts and anesthetic records of the 12 infants and children who received the left lateral hepatic segment from a living relative the past 2 years at our institution were reviewed. The records were examined to determine the causes of perioperative morbidity and to identify patients at high risk for serious complications and mortality. All infants and children (mean ± SD age, 29 ± 30 months; weight, 13.6 ± 6.8 kg) survived the operation (8.3 ± 1.7 hours) without intraoperative complications. The average blood loss, including 500 mL of recipient blood used to flush the liver before reperfusion, was 1483 ± 873 mL (119 ± 70 mL/kg). Three infants developed portal vein thrombosis, and one of these infants also had hepatic artery thrombosis. The risk of vessel thrombosis was significantly higher (3/3 vs. 0/9; p < 0.0045) in infants less than 9 kg body weight, as was the risk of death (2/3 vs. 0/9; p < 0.045). Both children who died had vascular thrombosis. Other serious complications were bleeding, 6; infection, 7; acute rejection, 3; and bile leak, 2. Conclusions: Infants and children can successfully undergo living, related liver transplantation. However, the risks of vascular complications and death are greater in infants less than 9 kg body weight. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)454-459
Number of pages6
JournalJournal of Clinical Anesthesia
Volume12
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Postoperative Care
Liver Transplantation
Anesthetics
Morbidity
Mortality
Thrombosis
Blood Vessels
Body Weight
Liver
Hepatic Artery
Urban Hospitals
Intraoperative Complications
Portal Vein
Bile
Teaching Hospitals
Reperfusion
Hemorrhage
Weights and Measures
Infection

Keywords

  • Anesthesia, complications
  • Living, related liver transplantation
  • Mortality, pediatric

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Living related liver transplantation in infants and children : Report of anesthetic care and early postoperative morbidity and mortality. / Wagner, Claudia; Beebe, David S.; Carr, Richard J.; Komanduri, Vijaya; Humar, Abhinav; Gruessner, Rainer W G; Belani, Kumar G.

In: Journal of Clinical Anesthesia, Vol. 12, No. 6, 2000, p. 454-459.

Research output: Contribution to journalArticle

Wagner, Claudia ; Beebe, David S. ; Carr, Richard J. ; Komanduri, Vijaya ; Humar, Abhinav ; Gruessner, Rainer W G ; Belani, Kumar G. / Living related liver transplantation in infants and children : Report of anesthetic care and early postoperative morbidity and mortality. In: Journal of Clinical Anesthesia. 2000 ; Vol. 12, No. 6. pp. 454-459.
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