Localisation of glucose transport in the ruminant placenta: Implications for sequential use of transporter isoforms

F. B P Wooding, A. L. Fowden, A. W. Bell, R. A. Ehrhardt, Sean W Limesand, W. W. Hay

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The facilitative glucose transporters 1 and 3 are the major routes for glucose transport across placental membranes. Using light and electron microscope immunocytochemistry on acrylic sections this study shows a similar pattern of expression from mid to late pregnancy in all four ruminants examined [cow, deer, ewe and goat]. GT1 and GT3 are localised on different membrane layers of the synepitheliochorial placental barrier and glucose must utilise both isoforms sequentially to pass from the maternal to fetal circulations. It is suggested that this arrangement is designed to support the high glucose utilisation by the multilayered placenta in the ruminant.

Original languageEnglish (US)
Pages (from-to)626-640
Number of pages15
JournalPlacenta
Volume26
Issue number8-9
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

Ruminants
Placenta
Protein Isoforms
Glucose
Deer
Membranes
Facilitative Glucose Transport Proteins
Goats
Immunohistochemistry
Mothers
Electrons
Light
Pregnancy

Keywords

  • Cow
  • Deer
  • Glucose transport
  • Glucose transporter isoform localisation
  • Goat
  • Light and electron microscope immunocytochemistry
  • Ruminant placenta
  • Sheep placentas

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Localisation of glucose transport in the ruminant placenta : Implications for sequential use of transporter isoforms. / Wooding, F. B P; Fowden, A. L.; Bell, A. W.; Ehrhardt, R. A.; Limesand, Sean W; Hay, W. W.

In: Placenta, Vol. 26, No. 8-9, 09.2005, p. 626-640.

Research output: Contribution to journalArticle

Wooding, F. B P ; Fowden, A. L. ; Bell, A. W. ; Ehrhardt, R. A. ; Limesand, Sean W ; Hay, W. W. / Localisation of glucose transport in the ruminant placenta : Implications for sequential use of transporter isoforms. In: Placenta. 2005 ; Vol. 26, No. 8-9. pp. 626-640.
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