Localization of androgen receptor within peptidergic neurons of the rat forebrain

Elena W. Bingaman, Lori M. Baeckman, Joseph M. Yracheta, Robert J Handa, Thackery S. Gray

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

This study tested for the presence of androgen receptor-immunoreactivity in somatostatin, galanin, vasopressin, corticotropin-releasing hormone, and oxytocin neurons in the rat forebrain. The brains of adult male Sprague-Dawley rats were fixed with 4% paraformaldehyde. Androgen receptor was visualized in coronal sections using nickel intensification of diaminobenzidine, and the neuropeptides were identified using a brown diaminobenzidine reaction product. Androgen receptor was localized to the nuclei of neurons in the septum, amygdala, cortex, hippocampus, and hypothalamus. The majority of somatostatin-containing neurons in the periventricular hypothalamic nucleus also contained androgen receptor. Androgen receptor was also found within galanin-expressing cells in the bed nucleus of the stria terminalis and in the amygdala. Androgen receptor was not observed in corticotropin-releasing hormone, vasopressin, or oxytocin neurons in all areas examined. The data suggest that androgens may be capable of directly regulating somatostatin-expressing neurons of the periventricular nucleus of the hypothalamus and galanin-containing neurons of the bed nucleus of the stria terminalis and amygdala.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalBrain Research Bulletin
Volume35
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Androgen Receptors
Prosencephalon
Galanin
Neurons
Somatostatin
Amygdala
Septal Nuclei
Corticotropin-Releasing Hormone
Oxytocin
Vasopressins
Hypothalamus
Nickel
Neuropeptides
Androgens
Sprague Dawley Rats
Hippocampus
Brain

Keywords

  • Androgen receptor
  • CRH
  • Galanin
  • Somatostatin
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Localization of androgen receptor within peptidergic neurons of the rat forebrain. / Bingaman, Elena W.; Baeckman, Lori M.; Yracheta, Joseph M.; Handa, Robert J; Gray, Thackery S.

In: Brain Research Bulletin, Vol. 35, No. 4, 1994, p. 379-382.

Research output: Contribution to journalArticle

Bingaman, Elena W. ; Baeckman, Lori M. ; Yracheta, Joseph M. ; Handa, Robert J ; Gray, Thackery S. / Localization of androgen receptor within peptidergic neurons of the rat forebrain. In: Brain Research Bulletin. 1994 ; Vol. 35, No. 4. pp. 379-382.
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