Localization of choriocarcinoma by 131I-βHCG antibody

Kenneth D Hatch, William J. Mann, Larry R. Boots, W. Newton Tauxe, Hugh M. Shingleton, Ernest S. Buchina

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A patient is presented who was cured surgically of metastatic gestational trophoblastic disease (GTD), of high-risk category, after the localization of tumor by radioactive antibody to HCG. The patient was initially treated with hysterectomy and resection of involved bowel; disease recurred, and conventional triple-agent chemotherapy failed, as well as less established multidrug reginens. Rabbit antibody to β-HCG was labeled with 131I and injected into the patient. Scintigrams localized the metastatic disease, allowing resection and cure. This methodology may offer a potential means of utilizing surgery to cure select patients who have failed triple-agent therapy and whose prognosis is poor if treated conventionally.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalGynecologic Oncology
Volume10
Issue number3
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Choriocarcinoma
Antibodies
Gestational Trophoblastic Disease
Neoplasm Antibodies
Hysterectomy
Rabbits
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Hatch, K. D., Mann, W. J., Boots, L. R., Tauxe, W. N., Shingleton, H. M., & Buchina, E. S. (1980). Localization of choriocarcinoma by 131I-βHCG antibody. Gynecologic Oncology, 10(3), 253-261. https://doi.org/10.1016/0090-8258(80)90091-8

Localization of choriocarcinoma by 131I-βHCG antibody. / Hatch, Kenneth D; Mann, William J.; Boots, Larry R.; Tauxe, W. Newton; Shingleton, Hugh M.; Buchina, Ernest S.

In: Gynecologic Oncology, Vol. 10, No. 3, 1980, p. 253-261.

Research output: Contribution to journalArticle

Hatch, KD, Mann, WJ, Boots, LR, Tauxe, WN, Shingleton, HM & Buchina, ES 1980, 'Localization of choriocarcinoma by 131I-βHCG antibody', Gynecologic Oncology, vol. 10, no. 3, pp. 253-261. https://doi.org/10.1016/0090-8258(80)90091-8
Hatch, Kenneth D ; Mann, William J. ; Boots, Larry R. ; Tauxe, W. Newton ; Shingleton, Hugh M. ; Buchina, Ernest S. / Localization of choriocarcinoma by 131I-βHCG antibody. In: Gynecologic Oncology. 1980 ; Vol. 10, No. 3. pp. 253-261.
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