Localization of receptors for activated complement on visceral epithelial cells of the human renal glomerulus

M. L. Shin, M. C. Gelfand, Raymond B Nagle, J. R. Carlo, I. Green, M. M. Frank

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Receptors for activated C3 have recently been demonstrated to be present in glomeruli of normal human kidneys. In the present communication, the precise location of these receptors within the renal corpuscle was studied with scanning electron microscopy. By this technique, the glomerular complement receptor (GCR) was found to be located on the visceral epithelial cell of the renal corpuscle. This epithelial cell location was confirmed by comparison of in vitro GCR activity with the location of immunoglobulin and C3 deposited in vivo. Renal tissues in which Ig and C3 had been deposited in vivo diffusely in subepithelial loci had no in vitro GCR activity. Renal biopsies not showing Ig or C3 deposition or biopsies with Ig and C3 in the mesangium retained GCR activity. These results further confirm an important role for GCR in the trapping and deposition of C3 in some forms of immunologically mediated renal disease.

Original languageEnglish (US)
Pages (from-to)869-873
Number of pages5
JournalJournal of Immunology
Volume118
Issue number3
StatePublished - 1977
Externally publishedYes

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Complement Receptors
Epithelial Cells
Kidney
Glomerular Mesangium
Biopsy
Electron Scanning Microscopy
Immunoglobulins

ASJC Scopus subject areas

  • Immunology

Cite this

Shin, M. L., Gelfand, M. C., Nagle, R. B., Carlo, J. R., Green, I., & Frank, M. M. (1977). Localization of receptors for activated complement on visceral epithelial cells of the human renal glomerulus. Journal of Immunology, 118(3), 869-873.

Localization of receptors for activated complement on visceral epithelial cells of the human renal glomerulus. / Shin, M. L.; Gelfand, M. C.; Nagle, Raymond B; Carlo, J. R.; Green, I.; Frank, M. M.

In: Journal of Immunology, Vol. 118, No. 3, 1977, p. 869-873.

Research output: Contribution to journalArticle

Shin, ML, Gelfand, MC, Nagle, RB, Carlo, JR, Green, I & Frank, MM 1977, 'Localization of receptors for activated complement on visceral epithelial cells of the human renal glomerulus', Journal of Immunology, vol. 118, no. 3, pp. 869-873.
Shin, M. L. ; Gelfand, M. C. ; Nagle, Raymond B ; Carlo, J. R. ; Green, I. ; Frank, M. M. / Localization of receptors for activated complement on visceral epithelial cells of the human renal glomerulus. In: Journal of Immunology. 1977 ; Vol. 118, No. 3. pp. 869-873.
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