Localization of specific neurotensin binding sites in the rat adrenal gland

M. Goedert, Patrick W Mantyh, S. P. Hunt, P. C. Emson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Specific tritiated neurotensin binding sites were localized in the rat adrenal gland by receptor autoradiography and characterized using a tissue homogenate receptor binding assay. High levels of specific neurotensin binding sites were found in the inner layer of the adrenal cortex and lower amounts in the adrenal medulla with only background labeling in the outer cortical layers. The structure-activity profile of the specific neurotensin binding was consistent with binding to a physiological neurotensin receptor.

Original languageEnglish (US)
Pages (from-to)389-392
Number of pages4
JournalBrain Research
Volume299
Issue number2
DOIs
StatePublished - May 14 1984
Externally publishedYes

Fingerprint

Neurotensin
Adrenal Glands
Binding Sites
Neurotensin Receptors
Adrenal Medulla
Adrenal Cortex
Autoradiography

Keywords

  • adrenal cortex
  • adrenal medulla
  • receptor autoradiography
  • [H]neurotensin binding

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Localization of specific neurotensin binding sites in the rat adrenal gland. / Goedert, M.; Mantyh, Patrick W; Hunt, S. P.; Emson, P. C.

In: Brain Research, Vol. 299, No. 2, 14.05.1984, p. 389-392.

Research output: Contribution to journalArticle

Goedert, M. ; Mantyh, Patrick W ; Hunt, S. P. ; Emson, P. C. / Localization of specific neurotensin binding sites in the rat adrenal gland. In: Brain Research. 1984 ; Vol. 299, No. 2. pp. 389-392.
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