Localization of specific neurotensin binding sites in the rat adrenal gland

M. Goedert, Patrick W Mantyh, S. P. Hunt, P. C. Emson

Research output: Contribution to journalArticle

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Abstract

Specific tritiated neurotensin binding sites were localized in the rat adrenal gland by receptor autoradiography and characterized using a tissue homogenate receptor binding assay. High levels of specific neurotensin binding sites were found in the inner layer of the adrenal cortex and lower amounts in the adrenal medulla with only background labeling in the outer cortical layers. The structure-activity profile of the specific neurotensin binding was consistent with binding to a physiological neurotensin receptor.

Original languageEnglish (US)
Pages (from-to)389-392
Number of pages4
JournalBrain Research
Volume299
Issue number2
DOIs
Publication statusPublished - May 14 1984
Externally publishedYes

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Keywords

  • adrenal cortex
  • adrenal medulla
  • receptor autoradiography
  • [H]neurotensin binding

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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