Location specific radiographic joint space width for osteoarthritis progression

G. Neumann, D. Hunter, M. Nevitt, L. B. Chibnik, Chian K Kwoh, H. Chen, T. Harris, S. Satterfield, J. Duryea

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objective: To establish the performance of location specific computer measures of radiographic joint space width (JSW) compared to measurements of minimum joint space width (mJSW) for the assessment of medial compartment knee osteoarthritis (OA). The study also investigated the most disease-responsive location for measuring medial compartment JSW. Methods: Serial bilateral Posterior Anterior (PA) conventional radiographs acquired with a fixed flexion protocol were obtained 36 months apart in 118 persons with knee OA participating in the Health, Aging and Body Composition (Health ABC) Study. Measurements of medial compartment mJSW and JSW at seven fixed locations were facilitated by the use of semi-automated software that delineated the femoral and tibial margins of the joint. A human reader operated custom software to verify and correct the software-drawn margins where necessary. Paired images were displayed with the reader blinded to the chronological order. The amount of joint space narrowing was measured and the standardized response mean (SRM) was used as a metric to quantify performance. Results: For all subjects, the mJSW SRM value was 0.42 while, for the most responsive location specific measure of JSW, it was SRM = 0.46. For subjects with a Kellgren-Lawrence (KL) score less than or equal to 1, mJSW (SRM = 0.40) was more responsive than the new measures (Maximum SRM = 0.30). For KL = 2 or 3, SRM = 0.49 for mJSW, and SRM = 0.74 for the most responsive location specific measure of JSW. Improved responsiveness was observed in the more central portion of the joint on the more diseased knees. Conclusions: Location specific computer measures of JSW are feasible and potentially provide a superior method to assess radiographic OA for more diseased subjects. This new measure has the potential to improve the power of clinical studies that use a fixed flexion protocol.

Original languageEnglish (US)
Pages (from-to)761-765
Number of pages5
JournalOsteoarthritis and Cartilage
Volume17
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Osteoarthritis
Joints
Software
Knee Osteoarthritis
Aging of materials
Health
Chemical analysis
Thigh
Body Composition
Knee

ASJC Scopus subject areas

  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Location specific radiographic joint space width for osteoarthritis progression. / Neumann, G.; Hunter, D.; Nevitt, M.; Chibnik, L. B.; Kwoh, Chian K; Chen, H.; Harris, T.; Satterfield, S.; Duryea, J.

In: Osteoarthritis and Cartilage, Vol. 17, No. 6, 06.2009, p. 761-765.

Research output: Contribution to journalArticle

Neumann, G, Hunter, D, Nevitt, M, Chibnik, LB, Kwoh, CK, Chen, H, Harris, T, Satterfield, S & Duryea, J 2009, 'Location specific radiographic joint space width for osteoarthritis progression', Osteoarthritis and Cartilage, vol. 17, no. 6, pp. 761-765. https://doi.org/10.1016/j.joca.2008.11.001
Neumann, G. ; Hunter, D. ; Nevitt, M. ; Chibnik, L. B. ; Kwoh, Chian K ; Chen, H. ; Harris, T. ; Satterfield, S. ; Duryea, J. / Location specific radiographic joint space width for osteoarthritis progression. In: Osteoarthritis and Cartilage. 2009 ; Vol. 17, No. 6. pp. 761-765.
@article{200cad177d784a3ca688d968faf935df,
title = "Location specific radiographic joint space width for osteoarthritis progression",
abstract = "Objective: To establish the performance of location specific computer measures of radiographic joint space width (JSW) compared to measurements of minimum joint space width (mJSW) for the assessment of medial compartment knee osteoarthritis (OA). The study also investigated the most disease-responsive location for measuring medial compartment JSW. Methods: Serial bilateral Posterior Anterior (PA) conventional radiographs acquired with a fixed flexion protocol were obtained 36 months apart in 118 persons with knee OA participating in the Health, Aging and Body Composition (Health ABC) Study. Measurements of medial compartment mJSW and JSW at seven fixed locations were facilitated by the use of semi-automated software that delineated the femoral and tibial margins of the joint. A human reader operated custom software to verify and correct the software-drawn margins where necessary. Paired images were displayed with the reader blinded to the chronological order. The amount of joint space narrowing was measured and the standardized response mean (SRM) was used as a metric to quantify performance. Results: For all subjects, the mJSW SRM value was 0.42 while, for the most responsive location specific measure of JSW, it was SRM = 0.46. For subjects with a Kellgren-Lawrence (KL) score less than or equal to 1, mJSW (SRM = 0.40) was more responsive than the new measures (Maximum SRM = 0.30). For KL = 2 or 3, SRM = 0.49 for mJSW, and SRM = 0.74 for the most responsive location specific measure of JSW. Improved responsiveness was observed in the more central portion of the joint on the more diseased knees. Conclusions: Location specific computer measures of JSW are feasible and potentially provide a superior method to assess radiographic OA for more diseased subjects. This new measure has the potential to improve the power of clinical studies that use a fixed flexion protocol.",
author = "G. Neumann and D. Hunter and M. Nevitt and Chibnik, {L. B.} and Kwoh, {Chian K} and H. Chen and T. Harris and S. Satterfield and J. Duryea",
year = "2009",
month = "6",
doi = "10.1016/j.joca.2008.11.001",
language = "English (US)",
volume = "17",
pages = "761--765",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Location specific radiographic joint space width for osteoarthritis progression

AU - Neumann, G.

AU - Hunter, D.

AU - Nevitt, M.

AU - Chibnik, L. B.

AU - Kwoh, Chian K

AU - Chen, H.

AU - Harris, T.

AU - Satterfield, S.

AU - Duryea, J.

PY - 2009/6

Y1 - 2009/6

N2 - Objective: To establish the performance of location specific computer measures of radiographic joint space width (JSW) compared to measurements of minimum joint space width (mJSW) for the assessment of medial compartment knee osteoarthritis (OA). The study also investigated the most disease-responsive location for measuring medial compartment JSW. Methods: Serial bilateral Posterior Anterior (PA) conventional radiographs acquired with a fixed flexion protocol were obtained 36 months apart in 118 persons with knee OA participating in the Health, Aging and Body Composition (Health ABC) Study. Measurements of medial compartment mJSW and JSW at seven fixed locations were facilitated by the use of semi-automated software that delineated the femoral and tibial margins of the joint. A human reader operated custom software to verify and correct the software-drawn margins where necessary. Paired images were displayed with the reader blinded to the chronological order. The amount of joint space narrowing was measured and the standardized response mean (SRM) was used as a metric to quantify performance. Results: For all subjects, the mJSW SRM value was 0.42 while, for the most responsive location specific measure of JSW, it was SRM = 0.46. For subjects with a Kellgren-Lawrence (KL) score less than or equal to 1, mJSW (SRM = 0.40) was more responsive than the new measures (Maximum SRM = 0.30). For KL = 2 or 3, SRM = 0.49 for mJSW, and SRM = 0.74 for the most responsive location specific measure of JSW. Improved responsiveness was observed in the more central portion of the joint on the more diseased knees. Conclusions: Location specific computer measures of JSW are feasible and potentially provide a superior method to assess radiographic OA for more diseased subjects. This new measure has the potential to improve the power of clinical studies that use a fixed flexion protocol.

AB - Objective: To establish the performance of location specific computer measures of radiographic joint space width (JSW) compared to measurements of minimum joint space width (mJSW) for the assessment of medial compartment knee osteoarthritis (OA). The study also investigated the most disease-responsive location for measuring medial compartment JSW. Methods: Serial bilateral Posterior Anterior (PA) conventional radiographs acquired with a fixed flexion protocol were obtained 36 months apart in 118 persons with knee OA participating in the Health, Aging and Body Composition (Health ABC) Study. Measurements of medial compartment mJSW and JSW at seven fixed locations were facilitated by the use of semi-automated software that delineated the femoral and tibial margins of the joint. A human reader operated custom software to verify and correct the software-drawn margins where necessary. Paired images were displayed with the reader blinded to the chronological order. The amount of joint space narrowing was measured and the standardized response mean (SRM) was used as a metric to quantify performance. Results: For all subjects, the mJSW SRM value was 0.42 while, for the most responsive location specific measure of JSW, it was SRM = 0.46. For subjects with a Kellgren-Lawrence (KL) score less than or equal to 1, mJSW (SRM = 0.40) was more responsive than the new measures (Maximum SRM = 0.30). For KL = 2 or 3, SRM = 0.49 for mJSW, and SRM = 0.74 for the most responsive location specific measure of JSW. Improved responsiveness was observed in the more central portion of the joint on the more diseased knees. Conclusions: Location specific computer measures of JSW are feasible and potentially provide a superior method to assess radiographic OA for more diseased subjects. This new measure has the potential to improve the power of clinical studies that use a fixed flexion protocol.

UR - http://www.scopus.com/inward/record.url?scp=67349186855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349186855&partnerID=8YFLogxK

U2 - 10.1016/j.joca.2008.11.001

DO - 10.1016/j.joca.2008.11.001

M3 - Article

C2 - 19073368

AN - SCOPUS:67349186855

VL - 17

SP - 761

EP - 765

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 6

ER -