Long-axis specialization of the human hippocampus

Jordan Poppenk, Hallvard R. Evensmoen, Morris Moscovitch, Lynn Nadel

Research output: Contribution to journalReview article

418 Scopus citations

Abstract

Investigation of the hippocampus has historically focused on computations within the trisynaptic circuit. However, discovery of important anatomical and functional variability along its long axis has inspired recent proposals of long-axis functional specialization in both the animal and human literatures. Here, we review and evaluate these proposals. We suggest that various long-axis specializations arise out of differences between the anterior (aHPC) and posterior hippocampus (pHPC) in large-scale network connectivity, the organization of entorhinal grid cells, and subfield compositions that bias the aHPC and pHPC towards pattern completion and separation, respectively. The latter two differences give rise to a property, reflected in the expression of multiple other functional specializations, of coarse, global representations in anterior hippocampus and fine-grained, local representations in posterior hippocampus.

Original languageEnglish (US)
Pages (from-to)230-240
Number of pages11
JournalTrends in Cognitive Sciences
Volume17
Issue number5
DOIs
StatePublished - May 1 2013

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

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