Long-term facilitation of upper airway muscle activities in vagotomized and vagally intact cats

J. H. Mateika, R. F. Fregosi

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

The primary purpose of the present investigation was to determine whether long-term facilitation (LTF) of upper airway muscle activities occurs in vagotomized and vagally intact cats. Tidal volume and diaphragm, genioglossus, and nasal dilator muscle activities were recorded before, during, and after one carotid sinus nerve was stimulated five times with 2- min trains of constant current. Sixty minutes after stimulation, nasal dilator and genioglossus muscle activities were significantly greater than control in the vagotomized cats but not in the vagally intact cats. Tidal volume recorded from the vagotomized and vagally intact cats was significantly greater than control during the poststimulation period. In contrast, diaphragm activities were not significantly elevated in the poststimulation period in either group of animals. We conclude that 1) LTF of genioglossus and nasal dilator muscle activities can be evoked in vagotomized cats; 2) vagal mechanisms inhibit LTF in upper airway muscles; and 3) LTF can be evoked in accessory inspiratory muscles because LTF of inspired tidal volume was greater than LTF of diaphragm activity.

Original languageEnglish (US)
Pages (from-to)419-425
Number of pages7
JournalJournal of Applied Physiology
Volume82
Issue number2
DOIs
StatePublished - Feb 1997

Keywords

  • carotid sinus nerve
  • genioglossus muscle
  • nasal dilator muscle
  • vagal inhibitory memory

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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