Long-term outcome following programmed electrical stimulation in patients with high-grade ventricular ectopy

M. H. Kharsa, R. L. Gold, H. Moore, Y. Yazaki, C. I. Haffajee, Joseph S Alpert

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

To determine if programmed electrical stimulation (PES) could be utilized to identify patients with high-grade ventricular ectopy at low- or high-risk for sudden cardiac death, we performed PES in 40 patients with high-grade ventricular ectopy refractory to conventional antiarrhythmic agents. Twenty-one patients had a previous myocardial infarction, five had cardiomyopathy, six had hypertension, three had valvular heart disease and five had no known structural heart disease. The mean age was 60 years (range, 18 to 76). During programmed ventricular stimulation, eight patients had inducible sustained (more than 30 seconds) monomorphic ventricular tachycardia (Group I) but in 32 patients sustained ventricular tachycardia was not inducible (Group II). None of the five patients without structural heart disease were inducible while seven out of 21 (33%) patients with previous myocardial infarction had inducible ventricular tachycardia (VT). Antiarrhythmic therapy was instituted in patients with inducible VT; patients without inducible VT did not receive antiarrhythmic agents. In Group I, seven of the eight patients are alive (mean follow-up, 16 months) and in Group II, 28 of the 32 patients are alive (mean follow-up, 17 months). None of the five deaths were sudden. We conclude that in the absence of antiarrhythmic therapy, the incidence of sudden cardiac death is very low in patients with high-grade ventricular ectopy who do not have inducible monomorphic ventricular tachycardia during programmed ventricular stimulation.

Original languageEnglish (US)
Pages (from-to)603-609
Number of pages7
JournalPACE - Pacing and Clinical Electrophysiology
Volume11
Issue number5
StatePublished - 1988
Externally publishedYes

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Electric Stimulation
Ventricular Tachycardia
Sudden Cardiac Death
Heart Diseases
Myocardial Infarction
Heart Valve Diseases
Sudden Death
Cardiomyopathies
Hypertension
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Long-term outcome following programmed electrical stimulation in patients with high-grade ventricular ectopy. / Kharsa, M. H.; Gold, R. L.; Moore, H.; Yazaki, Y.; Haffajee, C. I.; Alpert, Joseph S.

In: PACE - Pacing and Clinical Electrophysiology, Vol. 11, No. 5, 1988, p. 603-609.

Research output: Contribution to journalArticle

Kharsa, M. H. ; Gold, R. L. ; Moore, H. ; Yazaki, Y. ; Haffajee, C. I. ; Alpert, Joseph S. / Long-term outcome following programmed electrical stimulation in patients with high-grade ventricular ectopy. In: PACE - Pacing and Clinical Electrophysiology. 1988 ; Vol. 11, No. 5. pp. 603-609.
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