Long-term potentiation and the ageing brain

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations

Abstract

Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.

Original languageEnglish (US)
Pages (from-to)765-772
Number of pages8
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume358
Issue number1432
DOIs
StatePublished - Apr 29 2003

Keywords

  • Ageing
  • Hippocampus
  • Learning
  • Long-term potentiation
  • Memory

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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