Long-term surface cortical cerebral blood flow monitoring in temporal lobe epilepsy

Martin E Weinand, L. P. Carter, D. D. Patton, K. J. Oommen, David M Labiner, D. Talwar, R. G. Grossman, A. R. Wyler

Research output: Contribution to journalArticle

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Abstract

LONG-TERM SUBDURAL SURFACE cortical cerebral blood flow (CBF) and electrocorticographic monitoring was performed in 12 patients with complex partial seizures. A total of 40 seizures were analyzed. Baseline CBF values from nonepileptic and epileptic temporal lobe (mean ± standard error) were 60.0 ± 1.0 and 50.2 ± 1.8 ml/100 g per minute, respectively (P < 0.05). In general, clinical seizure onset was preceded by a 20-minute preictal CBF increase from baseline in the epileptic temporal lobe. Peak early postictal CBF values of nonepileptic and epileptic temporal lobes were 57.7 ± 13.3 and 89.0 ± 21.7 ml/100 g per minute (P > 0.05) at 5.2 ± 2.2 and 2.4 ± 1.0 minutes (P > 0.05) after clinical seizure onset, respectively. Statistically significant differences between nonepileptic and epileptic temporal lobe CBF were detected at 50 minutes (74.0 ± 14.2 and 37.5 ± 9.2 ml/100 g per minute, respectively; P < 0.05) and 60 minutes (75.6 ± 13.6 and 36.1 ± 8.5 ml/100 g per minute, respectively; P < 0.05) postictal. The data suggest that the optimal times for CBF analysis to differentiate epileptic from nonepileptic temporal lobe are 1) during the interictal period and 2) late (50 to 60 minutes) postictal. The results of this study should improve the understanding of the dynamic cerebral perfusion patterns in the epileptic human brain.

Original languageEnglish (US)
Pages (from-to)657-664
Number of pages8
JournalNeurosurgery
Volume35
Issue number4
StatePublished - 1994

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Cerebrovascular Circulation
Temporal Lobe Epilepsy
Temporal Lobe
Seizures
Perfusion
Brain

Keywords

  • Cerebral blood flow
  • Subdural electrode
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Weinand, M. E., Carter, L. P., Patton, D. D., Oommen, K. J., Labiner, D. M., Talwar, D., ... Wyler, A. R. (1994). Long-term surface cortical cerebral blood flow monitoring in temporal lobe epilepsy. Neurosurgery, 35(4), 657-664.

Long-term surface cortical cerebral blood flow monitoring in temporal lobe epilepsy. / Weinand, Martin E; Carter, L. P.; Patton, D. D.; Oommen, K. J.; Labiner, David M; Talwar, D.; Grossman, R. G.; Wyler, A. R.

In: Neurosurgery, Vol. 35, No. 4, 1994, p. 657-664.

Research output: Contribution to journalArticle

Weinand, ME, Carter, LP, Patton, DD, Oommen, KJ, Labiner, DM, Talwar, D, Grossman, RG & Wyler, AR 1994, 'Long-term surface cortical cerebral blood flow monitoring in temporal lobe epilepsy', Neurosurgery, vol. 35, no. 4, pp. 657-664.
Weinand, Martin E ; Carter, L. P. ; Patton, D. D. ; Oommen, K. J. ; Labiner, David M ; Talwar, D. ; Grossman, R. G. ; Wyler, A. R. / Long-term surface cortical cerebral blood flow monitoring in temporal lobe epilepsy. In: Neurosurgery. 1994 ; Vol. 35, No. 4. pp. 657-664.
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