Long-term synaptic enhancement in hippocampus is not regulated by postsynaptic membrane potential

H. Wigström, B. L. McNaughton, C. A. Barnes

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The contributions of membrane potential and postsynaptic discharge during afferent fibre tetanization to the generation of long-lasting synaptic enhancement was studied by intra- and extracellular recording in the CA1 region of hippocampal slices. Neither parameter affected the magnitude of intracellular synaptic enhancement. Thus, if postsynaptic integration is involved in the control of the enhancement process, the integration must be chemically rather than electrically mediated.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalBrain Research
Volume233
Issue number1
DOIs
StatePublished - Feb 4 1982
Externally publishedYes

Keywords

  • brain slice
  • hippocampus
  • membrane potential
  • pyramidal cells
  • rat
  • synaptic modification

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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