Longitudinal decline in lung function: Evaluation of interleukin-10 genetic polymorphisms in firefighters

Jefferey L Burgess, Maria A. Fierro, Robert Clark Lantz, Tracy A. Hysong, Joy E. Fleming, Richard Gerkin, Eva Hnizdo, Shannon M. Conley, Walter Klimecki

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

During annual medical monitoring, some firefighters are found to have rates of decline in forced expiratory volume in one second (FEV1) far exceeding their peers. Interleukin-10 (IL-10) suppresses inflammation, and single nucleotide polymorphisms (SNPs) in the IL-10 gene may confer variable susceptibility to more rapid decline in lung function. In 1204 firefighters with at least six annual FEV1 measurements, increased age and greater initial FEV1 were associated with more rapid decline in lung function. DNA collected from 379 of these firefighters was screened for IL-10 SNPs at -1117, -854, 919, 1668, and 1812. A statistically significant difference in decline in lung function was found based on genotyping at the 1668 SNP. Evaluation of gene polymorphisms regulating lung inflammation may help to explain some of the variation in rate of decline in lung function in firefighters.

Original languageEnglish (US)
Pages (from-to)1013-1022
Number of pages10
JournalJournal of occupational and environmental medicine / American College of Occupational and Environmental Medicine
Volume46
Issue number10
DOIs
StatePublished - Oct 2004

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Firefighters
Genetic Polymorphisms
Interleukin-10
Single Nucleotide Polymorphism
Lung
Forced Expiratory Volume
Genes
Pneumonia
Inflammation
DNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Longitudinal decline in lung function : Evaluation of interleukin-10 genetic polymorphisms in firefighters. / Burgess, Jefferey L; Fierro, Maria A.; Lantz, Robert Clark; Hysong, Tracy A.; Fleming, Joy E.; Gerkin, Richard; Hnizdo, Eva; Conley, Shannon M.; Klimecki, Walter.

In: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, Vol. 46, No. 10, 10.2004, p. 1013-1022.

Research output: Contribution to journalArticle

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