Longitudinal effects of passive smoking on pulmonary function in New Zealand children

Duane L Sherrill, Fernando Martinez, M. D. Lebowitz, M. D. Holdaway, E. M. Flannery, G. P. Herbison, W. R. Stanton, P. A. Silva, M. R. Sears

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

In this study we examined the longitudinal effects of smoke exposure on lung function in a cohort of New Zealand children observed from 9 to 15 yr of age. Possible exposures included in utero exposure from mothers smoking during pregnancy, passive smoke from parents, and active smoking by the children. Lung function measures of forced expiratory volume in one second (FEV1) and vital capacity (VC) were measured biennially and ratios (FEV1/VC) were computed. The data were analyzed using longitudinal methodology, and all subjects with at least one pulmonary function test and responses to the questions concerning smoke exposures were included (n = 634). Subjects reporting wheeze or asthma were examined as a separate subgroup. In the whole cohort, no significant detrimental effects were detected for absolute FEV1 or VC in either sex, related to active or passive smoke exposures. Parental smoking was, however, associated with persistent but mild and nonprogressive impairment of the FEV1/VC ratio in males, an effect that was present at the time lung function measurements were first made. This effect was not seen in females. In children with reported wheeze or asthma, parental smoking had progressive, more serious, and clinically significant effects on the FEV1/VC ratio among adolescents of both sexes, causing a mean reduction in FEV1/VC ratios by age 15 of 3.9% in males and 2.3% in females, in contrast to the observed increase in FEV1/VC ratios with age seen in nonexposed wheezing children. We conclude that passive smoking is a major contributing factor to the development and persistence of airflow limitation in wheezing children.

Original languageEnglish (US)
Pages (from-to)1136-1141
Number of pages6
JournalAmerican Review of Respiratory Disease
Volume145
Issue number5
StatePublished - 1992

Fingerprint

Tobacco Smoke Pollution
Vital Capacity
New Zealand
Lung
Smoke
Smoking
Respiratory Sounds
Asthma
Respiratory Function Tests
Forced Expiratory Volume
Longitudinal Studies
Parents
Mothers
Pregnancy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Sherrill, D. L., Martinez, F., Lebowitz, M. D., Holdaway, M. D., Flannery, E. M., Herbison, G. P., ... Sears, M. R. (1992). Longitudinal effects of passive smoking on pulmonary function in New Zealand children. American Review of Respiratory Disease, 145(5), 1136-1141.

Longitudinal effects of passive smoking on pulmonary function in New Zealand children. / Sherrill, Duane L; Martinez, Fernando; Lebowitz, M. D.; Holdaway, M. D.; Flannery, E. M.; Herbison, G. P.; Stanton, W. R.; Silva, P. A.; Sears, M. R.

In: American Review of Respiratory Disease, Vol. 145, No. 5, 1992, p. 1136-1141.

Research output: Contribution to journalArticle

Sherrill, DL, Martinez, F, Lebowitz, MD, Holdaway, MD, Flannery, EM, Herbison, GP, Stanton, WR, Silva, PA & Sears, MR 1992, 'Longitudinal effects of passive smoking on pulmonary function in New Zealand children', American Review of Respiratory Disease, vol. 145, no. 5, pp. 1136-1141.
Sherrill, Duane L ; Martinez, Fernando ; Lebowitz, M. D. ; Holdaway, M. D. ; Flannery, E. M. ; Herbison, G. P. ; Stanton, W. R. ; Silva, P. A. ; Sears, M. R. / Longitudinal effects of passive smoking on pulmonary function in New Zealand children. In: American Review of Respiratory Disease. 1992 ; Vol. 145, No. 5. pp. 1136-1141.
@article{725e4e2cd0974a13afabfd51292e1108,
title = "Longitudinal effects of passive smoking on pulmonary function in New Zealand children",
abstract = "In this study we examined the longitudinal effects of smoke exposure on lung function in a cohort of New Zealand children observed from 9 to 15 yr of age. Possible exposures included in utero exposure from mothers smoking during pregnancy, passive smoke from parents, and active smoking by the children. Lung function measures of forced expiratory volume in one second (FEV1) and vital capacity (VC) were measured biennially and ratios (FEV1/VC) were computed. The data were analyzed using longitudinal methodology, and all subjects with at least one pulmonary function test and responses to the questions concerning smoke exposures were included (n = 634). Subjects reporting wheeze or asthma were examined as a separate subgroup. In the whole cohort, no significant detrimental effects were detected for absolute FEV1 or VC in either sex, related to active or passive smoke exposures. Parental smoking was, however, associated with persistent but mild and nonprogressive impairment of the FEV1/VC ratio in males, an effect that was present at the time lung function measurements were first made. This effect was not seen in females. In children with reported wheeze or asthma, parental smoking had progressive, more serious, and clinically significant effects on the FEV1/VC ratio among adolescents of both sexes, causing a mean reduction in FEV1/VC ratios by age 15 of 3.9{\%} in males and 2.3{\%} in females, in contrast to the observed increase in FEV1/VC ratios with age seen in nonexposed wheezing children. We conclude that passive smoking is a major contributing factor to the development and persistence of airflow limitation in wheezing children.",
author = "Sherrill, {Duane L} and Fernando Martinez and Lebowitz, {M. D.} and Holdaway, {M. D.} and Flannery, {E. M.} and Herbison, {G. P.} and Stanton, {W. R.} and Silva, {P. A.} and Sears, {M. R.}",
year = "1992",
language = "English (US)",
volume = "145",
pages = "1136--1141",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "5",

}

TY - JOUR

T1 - Longitudinal effects of passive smoking on pulmonary function in New Zealand children

AU - Sherrill, Duane L

AU - Martinez, Fernando

AU - Lebowitz, M. D.

AU - Holdaway, M. D.

AU - Flannery, E. M.

AU - Herbison, G. P.

AU - Stanton, W. R.

AU - Silva, P. A.

AU - Sears, M. R.

PY - 1992

Y1 - 1992

N2 - In this study we examined the longitudinal effects of smoke exposure on lung function in a cohort of New Zealand children observed from 9 to 15 yr of age. Possible exposures included in utero exposure from mothers smoking during pregnancy, passive smoke from parents, and active smoking by the children. Lung function measures of forced expiratory volume in one second (FEV1) and vital capacity (VC) were measured biennially and ratios (FEV1/VC) were computed. The data were analyzed using longitudinal methodology, and all subjects with at least one pulmonary function test and responses to the questions concerning smoke exposures were included (n = 634). Subjects reporting wheeze or asthma were examined as a separate subgroup. In the whole cohort, no significant detrimental effects were detected for absolute FEV1 or VC in either sex, related to active or passive smoke exposures. Parental smoking was, however, associated with persistent but mild and nonprogressive impairment of the FEV1/VC ratio in males, an effect that was present at the time lung function measurements were first made. This effect was not seen in females. In children with reported wheeze or asthma, parental smoking had progressive, more serious, and clinically significant effects on the FEV1/VC ratio among adolescents of both sexes, causing a mean reduction in FEV1/VC ratios by age 15 of 3.9% in males and 2.3% in females, in contrast to the observed increase in FEV1/VC ratios with age seen in nonexposed wheezing children. We conclude that passive smoking is a major contributing factor to the development and persistence of airflow limitation in wheezing children.

AB - In this study we examined the longitudinal effects of smoke exposure on lung function in a cohort of New Zealand children observed from 9 to 15 yr of age. Possible exposures included in utero exposure from mothers smoking during pregnancy, passive smoke from parents, and active smoking by the children. Lung function measures of forced expiratory volume in one second (FEV1) and vital capacity (VC) were measured biennially and ratios (FEV1/VC) were computed. The data were analyzed using longitudinal methodology, and all subjects with at least one pulmonary function test and responses to the questions concerning smoke exposures were included (n = 634). Subjects reporting wheeze or asthma were examined as a separate subgroup. In the whole cohort, no significant detrimental effects were detected for absolute FEV1 or VC in either sex, related to active or passive smoke exposures. Parental smoking was, however, associated with persistent but mild and nonprogressive impairment of the FEV1/VC ratio in males, an effect that was present at the time lung function measurements were first made. This effect was not seen in females. In children with reported wheeze or asthma, parental smoking had progressive, more serious, and clinically significant effects on the FEV1/VC ratio among adolescents of both sexes, causing a mean reduction in FEV1/VC ratios by age 15 of 3.9% in males and 2.3% in females, in contrast to the observed increase in FEV1/VC ratios with age seen in nonexposed wheezing children. We conclude that passive smoking is a major contributing factor to the development and persistence of airflow limitation in wheezing children.

UR - http://www.scopus.com/inward/record.url?scp=0026795106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026795106&partnerID=8YFLogxK

M3 - Article

VL - 145

SP - 1136

EP - 1141

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 5

ER -