Longitudinal observational studies to study the efficacy-effectiveness gap in drug therapy: Application to mild and moderate dementia

Karen M. MacDonald, Stefaan Vancayzeele, Anne Deblander, Ivo L. Abraham

Research output: Contribution to journalReview article

4 Scopus citations


If well-designed, longitudinal observational studies (LOSs) can provide insights to the linkages between real-world outcomes and their multilevel determinants. In this article, some of the scientific and methodologic issues related to LOSs in pharmacotherapeutic evaluations are discussed. A case of such a study in the treatment of mild to moderate dementia is provided - a case in which a pharmaceutic sponsor addressing a medical question (long-term effectiveness) realized that caring for patients who have Alzheimer's disease involves the clinical community of caregivers, physicians, families, nurses, psychologists, and pharmacists, among others, and partnered with nurse researchers to design their inquiry. The authors conclude by presenting an argument for nurses to take the lead in effectiveness research.

Original languageEnglish (US)
Pages (from-to)105-117
Number of pages13
JournalNursing Clinics of North America
Issue number1
StatePublished - Mar 2006


ASJC Scopus subject areas

  • Nursing(all)

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