Longitudinal observational studies to study the efficacy-effectiveness gap in drug therapy: Application to mild and moderate dementia

Karen M. MacDonald, Stefaan Vancayzeele, Anne Deblander, Ivo L Abraham

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

If well-designed, longitudinal observational studies (LOSs) can provide insights to the linkages between real-world outcomes and their multilevel determinants. In this article, some of the scientific and methodologic issues related to LOSs in pharmacotherapeutic evaluations are discussed. A case of such a study in the treatment of mild to moderate dementia is provided - a case in which a pharmaceutic sponsor addressing a medical question (long-term effectiveness) realized that caring for patients who have Alzheimer's disease involves the clinical community of caregivers, physicians, families, nurses, psychologists, and pharmacists, among others, and partnered with nurse researchers to design their inquiry. The authors conclude by presenting an argument for nurses to take the lead in effectiveness research.

Original languageEnglish (US)
Pages (from-to)105-117
Number of pages13
JournalNursing Clinics of North America
Volume41
Issue number1
DOIs
StatePublished - Mar 2006

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Observational Studies
Longitudinal Studies
Dementia
Nurses
Drug Therapy
Family Physicians
Pharmacists
Caregivers
Alzheimer Disease
Research Personnel
Psychology
Research
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Longitudinal observational studies to study the efficacy-effectiveness gap in drug therapy : Application to mild and moderate dementia. / MacDonald, Karen M.; Vancayzeele, Stefaan; Deblander, Anne; Abraham, Ivo L.

In: Nursing Clinics of North America, Vol. 41, No. 1, 03.2006, p. 105-117.

Research output: Contribution to journalArticle

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