Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression

pilot data from the Osteoarthritis Initiative

Torben Dannhauer, Martina Sattler, Wolfgang Wirth, David J. Hunter, Chian K Kwoh, Felix Eckstein

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECT: Biomechanical measurement of muscle strength represents established technology in evaluating limb function. Yet, analysis of longitudinal change suffers from relatively large between-measurement variability. Here, we determine the sensitivity to change of magnetic resonance imaging (MRI)-based measurement of thigh muscle anatomical cross sectional areas (ACSAs) versus isometric strength in limbs with and without structural progressive knee osteoarthritis (KOA), with focus on the quadriceps.

MATERIALS AND METHODS: Of 625 "Osteoarthritis Initiative" participants with radiographic KOA, 20 had MRI cartilage and radiographic joint space width loss in the right knee isometric muscle strength measurement and axial T1-weighted spin-echo acquisitions of the thigh. Muscle ACSAs were determined from manual segmentation at 33% femoral length (distal to proximal).

RESULTS: In progressor knees, the reduction in quadriceps ACSA between baseline and 2-year follow-up was -2.8 ± 7.9 % (standardized response mean [SRM] = -0.35), and it was -1.8 ± 6.8% (SRM = -0.26) in matched, non-progressive KOA controls. The decline in extensor strength was more variable than that in ACSAs, both in progressors (-3.9 ± 20%; SRM = -0.20) and in non-progressive controls (-4.5 ± 28%; SRM = -0.16).

CONCLUSION: MRI-based analysis of quadriceps muscles ACSAs appears to be more sensitive to longitudinal change than isometric extensor strength and is suggestive of greater loss in limbs with structurally progressive KOA than in non-progressive controls.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume27
Issue number4
DOIs
StatePublished - Aug 1 2014
Externally publishedYes

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Knee Osteoarthritis
Osteoarthritis
Knee
Thigh
Magnetic Resonance Imaging
Muscles
Extremities
Muscle Strength
Quadriceps Muscle
Cartilage
Joints
Technology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{3b6b3b6d4cab4c00b9c161673a03edcc,
title = "Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative",
abstract = "OBJECT: Biomechanical measurement of muscle strength represents established technology in evaluating limb function. Yet, analysis of longitudinal change suffers from relatively large between-measurement variability. Here, we determine the sensitivity to change of magnetic resonance imaging (MRI)-based measurement of thigh muscle anatomical cross sectional areas (ACSAs) versus isometric strength in limbs with and without structural progressive knee osteoarthritis (KOA), with focus on the quadriceps.MATERIALS AND METHODS: Of 625 {"}Osteoarthritis Initiative{"} participants with radiographic KOA, 20 had MRI cartilage and radiographic joint space width loss in the right knee isometric muscle strength measurement and axial T1-weighted spin-echo acquisitions of the thigh. Muscle ACSAs were determined from manual segmentation at 33{\%} femoral length (distal to proximal).RESULTS: In progressor knees, the reduction in quadriceps ACSA between baseline and 2-year follow-up was -2.8 ± 7.9 {\%} (standardized response mean [SRM] = -0.35), and it was -1.8 ± 6.8{\%} (SRM = -0.26) in matched, non-progressive KOA controls. The decline in extensor strength was more variable than that in ACSAs, both in progressors (-3.9 ± 20{\%}; SRM = -0.20) and in non-progressive controls (-4.5 ± 28{\%}; SRM = -0.16).CONCLUSION: MRI-based analysis of quadriceps muscles ACSAs appears to be more sensitive to longitudinal change than isometric extensor strength and is suggestive of greater loss in limbs with structurally progressive KOA than in non-progressive controls.",
author = "Torben Dannhauer and Martina Sattler and Wolfgang Wirth and Hunter, {David J.} and Kwoh, {Chian K} and Felix Eckstein",
year = "2014",
month = "8",
day = "1",
doi = "10.1007/s10334-013-0418-z",
language = "English (US)",
volume = "27",
pages = "339--347",
journal = "Magnetic Resonance Materials in Physics, Biology, and Medicine",
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TY - JOUR

T1 - Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression

T2 - pilot data from the Osteoarthritis Initiative

AU - Dannhauer, Torben

AU - Sattler, Martina

AU - Wirth, Wolfgang

AU - Hunter, David J.

AU - Kwoh, Chian K

AU - Eckstein, Felix

PY - 2014/8/1

Y1 - 2014/8/1

N2 - OBJECT: Biomechanical measurement of muscle strength represents established technology in evaluating limb function. Yet, analysis of longitudinal change suffers from relatively large between-measurement variability. Here, we determine the sensitivity to change of magnetic resonance imaging (MRI)-based measurement of thigh muscle anatomical cross sectional areas (ACSAs) versus isometric strength in limbs with and without structural progressive knee osteoarthritis (KOA), with focus on the quadriceps.MATERIALS AND METHODS: Of 625 "Osteoarthritis Initiative" participants with radiographic KOA, 20 had MRI cartilage and radiographic joint space width loss in the right knee isometric muscle strength measurement and axial T1-weighted spin-echo acquisitions of the thigh. Muscle ACSAs were determined from manual segmentation at 33% femoral length (distal to proximal).RESULTS: In progressor knees, the reduction in quadriceps ACSA between baseline and 2-year follow-up was -2.8 ± 7.9 % (standardized response mean [SRM] = -0.35), and it was -1.8 ± 6.8% (SRM = -0.26) in matched, non-progressive KOA controls. The decline in extensor strength was more variable than that in ACSAs, both in progressors (-3.9 ± 20%; SRM = -0.20) and in non-progressive controls (-4.5 ± 28%; SRM = -0.16).CONCLUSION: MRI-based analysis of quadriceps muscles ACSAs appears to be more sensitive to longitudinal change than isometric extensor strength and is suggestive of greater loss in limbs with structurally progressive KOA than in non-progressive controls.

AB - OBJECT: Biomechanical measurement of muscle strength represents established technology in evaluating limb function. Yet, analysis of longitudinal change suffers from relatively large between-measurement variability. Here, we determine the sensitivity to change of magnetic resonance imaging (MRI)-based measurement of thigh muscle anatomical cross sectional areas (ACSAs) versus isometric strength in limbs with and without structural progressive knee osteoarthritis (KOA), with focus on the quadriceps.MATERIALS AND METHODS: Of 625 "Osteoarthritis Initiative" participants with radiographic KOA, 20 had MRI cartilage and radiographic joint space width loss in the right knee isometric muscle strength measurement and axial T1-weighted spin-echo acquisitions of the thigh. Muscle ACSAs were determined from manual segmentation at 33% femoral length (distal to proximal).RESULTS: In progressor knees, the reduction in quadriceps ACSA between baseline and 2-year follow-up was -2.8 ± 7.9 % (standardized response mean [SRM] = -0.35), and it was -1.8 ± 6.8% (SRM = -0.26) in matched, non-progressive KOA controls. The decline in extensor strength was more variable than that in ACSAs, both in progressors (-3.9 ± 20%; SRM = -0.20) and in non-progressive controls (-4.5 ± 28%; SRM = -0.16).CONCLUSION: MRI-based analysis of quadriceps muscles ACSAs appears to be more sensitive to longitudinal change than isometric extensor strength and is suggestive of greater loss in limbs with structurally progressive KOA than in non-progressive controls.

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U2 - 10.1007/s10334-013-0418-z

DO - 10.1007/s10334-013-0418-z

M3 - Article

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JF - Magnetic Resonance Materials in Physics, Biology, and Medicine

SN - 1352-8661

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