Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: Pilot data from the Osteoarthritis Initiative

Torben Dannhauer, Martina Sattler, Wolfgang Wirth, David J. Hunter, C. Kent Kwoh, Felix Eckstein

Research output: Contribution to journalArticle

19 Scopus citations


Object: Biomechanical measurement of muscle strength represents established technology in evaluating limb function. Yet, analysis of longitudinal change suffers from relatively large between-measurement variability. Here, we determine the sensitivity to change of magnetic resonance imaging (MRI)-based measurement of thigh muscle anatomical cross sectional areas (ACSAs) versus isometric strength in limbs with and without structural progressive knee osteoarthritis (KOA), with focus on the quadriceps. Materials and methods: Of 625 "Osteoarthritis Initiative" participants with radiographic KOA, 20 had MRI cartilage and radiographic joint space width loss in the right knee isometric muscle strength measurement and axial T1-weighted spin-echo acquisitions of the thigh. Muscle ACSAs were determined from manual segmentation at 33 % femoral length (distal to proximal). Results: In progressor knees, the reduction in quadriceps ACSA between baseline and 2-year follow-up was -2.8 ± 7.9 % (standardized response mean [SRM] = -0.35), and it was -1.8 ± 6.8 % (SRM = -0.26) in matched, non-progressive KOA controls. The decline in extensor strength was more variable than that in ACSAs, both in progressors (-3.9 ± 20 %; SRM = -0.20) and in non-progressive controls (-4.5 ± 28 %; SRM = -0.16). Conclusion: MRI-based analysis of quadriceps muscles ACSAs appears to be more sensitive to longitudinal change than isometric extensor strength and is suggestive of greater loss in limbs with structurally progressive KOA than in non-progressive controls.

Original languageEnglish (US)
Pages (from-to)339-347
Number of pages9
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Issue number4
StatePublished - Aug 2014
Externally publishedYes



  • Cross-sectional anatomy
  • Longitudinal studies
  • Muscle strength
  • Quadriceps muscle
  • Sensitivity

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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