Type 3c diabetes mellitus (T3cDM) is a type of pancreatogenic diabetes. This form of diabetes has been significantly underappreciated, but is now receiving increased attention because of the recent recognition of its high incidence in chronic pancreatitis (CP) and other pancreatic diseases with irreparable loss of acinar cells. CP-associated T3cDM is characterized by insulin insufficiency resulting from pancreatic exocrine damage. However, how loss of acinar cells leads to insulin insufficiency in CP is practically unknown. Based on our review of the relevant literature and studies in our laboratory, we propose that lost protection from acinar cell–secreted regenerating proteins results in injury of the islet β cells in CP. Validation of this model may help in better understanding of the pathophysiology of T3cDM.
|Original language||English (US)|
|Number of pages||8|
|Journal||Current Opinion in Endocrine and Metabolic Research|
|State||Published - Mar 2019|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism