Loss of Reg proteins’ protection of islet β cells in chronic pancreatitis: A potential mechanism for the pathogenesis of type 3c diabetes

Chongmin Huan, Albert Stanek, Cathy Mueller, Peiqi Ou, Sue Dong, Joshua Zhang, Ramy Abdel-Naby, Rainer W G Gruessner

Research output: Contribution to journalReview article

Abstract

Type 3c diabetes mellitus (T3cDM) is a type of pancreatogenic diabetes. This form of diabetes has been significantly underappreciated, but is now receiving increased attention because of the recent recognition of its high incidence in chronic pancreatitis (CP) and other pancreatic diseases with irreparable loss of acinar cells. CP-associated T3cDM is characterized by insulin insufficiency resulting from pancreatic exocrine damage. However, how loss of acinar cells leads to insulin insufficiency in CP is practically unknown. Based on our review of the relevant literature and studies in our laboratory, we propose that lost protection from acinar cell–secreted regenerating proteins results in injury of the islet β cells in CP. Validation of this model may help in better understanding of the pathophysiology of T3cDM.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalCurrent Opinion in Endocrine and Metabolic Research
Volume5
DOIs
StatePublished - Mar 1 2019
Externally publishedYes

Fingerprint

Chronic Pancreatitis
Islets of Langerhans
Diabetes Mellitus
Acinar Cells
Proteins
Insulin
Exocrine Pancreatic Insufficiency
Pancreatic Diseases
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Loss of Reg proteins’ protection of islet β cells in chronic pancreatitis : A potential mechanism for the pathogenesis of type 3c diabetes. / Huan, Chongmin; Stanek, Albert; Mueller, Cathy; Ou, Peiqi; Dong, Sue; Zhang, Joshua; Abdel-Naby, Ramy; Gruessner, Rainer W G.

In: Current Opinion in Endocrine and Metabolic Research, Vol. 5, 01.03.2019, p. 21-28.

Research output: Contribution to journalReview article

Huan, Chongmin ; Stanek, Albert ; Mueller, Cathy ; Ou, Peiqi ; Dong, Sue ; Zhang, Joshua ; Abdel-Naby, Ramy ; Gruessner, Rainer W G. / Loss of Reg proteins’ protection of islet β cells in chronic pancreatitis : A potential mechanism for the pathogenesis of type 3c diabetes. In: Current Opinion in Endocrine and Metabolic Research. 2019 ; Vol. 5. pp. 21-28.
@article{b281566ac840442b99174797df40812d,
title = "Loss of Reg proteins’ protection of islet β cells in chronic pancreatitis: A potential mechanism for the pathogenesis of type 3c diabetes",
abstract = "Type 3c diabetes mellitus (T3cDM) is a type of pancreatogenic diabetes. This form of diabetes has been significantly underappreciated, but is now receiving increased attention because of the recent recognition of its high incidence in chronic pancreatitis (CP) and other pancreatic diseases with irreparable loss of acinar cells. CP-associated T3cDM is characterized by insulin insufficiency resulting from pancreatic exocrine damage. However, how loss of acinar cells leads to insulin insufficiency in CP is practically unknown. Based on our review of the relevant literature and studies in our laboratory, we propose that lost protection from acinar cell–secreted regenerating proteins results in injury of the islet β cells in CP. Validation of this model may help in better understanding of the pathophysiology of T3cDM.",
author = "Chongmin Huan and Albert Stanek and Cathy Mueller and Peiqi Ou and Sue Dong and Joshua Zhang and Ramy Abdel-Naby and Gruessner, {Rainer W G}",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.coemr.2019.02.005",
language = "English (US)",
volume = "5",
pages = "21--28",
journal = "Current Opinion in Endocrine and Metabolic Research",
issn = "2451-9650",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Loss of Reg proteins’ protection of islet β cells in chronic pancreatitis

T2 - A potential mechanism for the pathogenesis of type 3c diabetes

AU - Huan, Chongmin

AU - Stanek, Albert

AU - Mueller, Cathy

AU - Ou, Peiqi

AU - Dong, Sue

AU - Zhang, Joshua

AU - Abdel-Naby, Ramy

AU - Gruessner, Rainer W G

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Type 3c diabetes mellitus (T3cDM) is a type of pancreatogenic diabetes. This form of diabetes has been significantly underappreciated, but is now receiving increased attention because of the recent recognition of its high incidence in chronic pancreatitis (CP) and other pancreatic diseases with irreparable loss of acinar cells. CP-associated T3cDM is characterized by insulin insufficiency resulting from pancreatic exocrine damage. However, how loss of acinar cells leads to insulin insufficiency in CP is practically unknown. Based on our review of the relevant literature and studies in our laboratory, we propose that lost protection from acinar cell–secreted regenerating proteins results in injury of the islet β cells in CP. Validation of this model may help in better understanding of the pathophysiology of T3cDM.

AB - Type 3c diabetes mellitus (T3cDM) is a type of pancreatogenic diabetes. This form of diabetes has been significantly underappreciated, but is now receiving increased attention because of the recent recognition of its high incidence in chronic pancreatitis (CP) and other pancreatic diseases with irreparable loss of acinar cells. CP-associated T3cDM is characterized by insulin insufficiency resulting from pancreatic exocrine damage. However, how loss of acinar cells leads to insulin insufficiency in CP is practically unknown. Based on our review of the relevant literature and studies in our laboratory, we propose that lost protection from acinar cell–secreted regenerating proteins results in injury of the islet β cells in CP. Validation of this model may help in better understanding of the pathophysiology of T3cDM.

UR - http://www.scopus.com/inward/record.url?scp=85063162506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063162506&partnerID=8YFLogxK

U2 - 10.1016/j.coemr.2019.02.005

DO - 10.1016/j.coemr.2019.02.005

M3 - Review article

AN - SCOPUS:85063162506

VL - 5

SP - 21

EP - 28

JO - Current Opinion in Endocrine and Metabolic Research

JF - Current Opinion in Endocrine and Metabolic Research

SN - 2451-9650

ER -