Abstract
Translational research programs offer incredible opportunities to bring cutting edge science into clinical practice. To facilitate these medical advances, funding agencies are increasingly focusing on a translational “payoff” within grant applications and larger programs. As this is the underlying promise of biomedical research—delivering advances to public health to improve the quality of life—such strategic initiatives are paramount. However, the process of taking experimental observations between model systems and human subjects can be extraordinarily frustrating. We brought together the collective expertise of our mouse and human immunology research programs to reverse engineer a clinical observation into a mouse model system. Our goal was to model (in mice) the age-related impaired delayed-type hypersensitivity response observed in humans, and then evaluate the efficacy of interventions to improve cutaneous immunity. We report here on what worked, what didn’t, and what we learned along the way.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 203-208 |
| Number of pages | 6 |
| Journal | Biogerontology |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2015 |
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Keywords
- Aging
- Delayed-type hypersensitivity
- Translational immunology
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Gerontology
- Aging
Cite this
Lost in translation : mice, men and cutaneous immunity in old age. / Smithey, Megan J; Uhrlaub, Jennifer L.; Li, Gang; Vukmanovic-Stejic, Milica; Akbar, Arne N.; Nikolich-Zugich, Janko.
In: Biogerontology, Vol. 16, No. 2, 2015, p. 203-208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lost in translation
T2 - mice, men and cutaneous immunity in old age
AU - Smithey, Megan J
AU - Uhrlaub, Jennifer L.
AU - Li, Gang
AU - Vukmanovic-Stejic, Milica
AU - Akbar, Arne N.
AU - Nikolich-Zugich, Janko
PY - 2015
Y1 - 2015
N2 - Translational research programs offer incredible opportunities to bring cutting edge science into clinical practice. To facilitate these medical advances, funding agencies are increasingly focusing on a translational “payoff” within grant applications and larger programs. As this is the underlying promise of biomedical research—delivering advances to public health to improve the quality of life—such strategic initiatives are paramount. However, the process of taking experimental observations between model systems and human subjects can be extraordinarily frustrating. We brought together the collective expertise of our mouse and human immunology research programs to reverse engineer a clinical observation into a mouse model system. Our goal was to model (in mice) the age-related impaired delayed-type hypersensitivity response observed in humans, and then evaluate the efficacy of interventions to improve cutaneous immunity. We report here on what worked, what didn’t, and what we learned along the way.
AB - Translational research programs offer incredible opportunities to bring cutting edge science into clinical practice. To facilitate these medical advances, funding agencies are increasingly focusing on a translational “payoff” within grant applications and larger programs. As this is the underlying promise of biomedical research—delivering advances to public health to improve the quality of life—such strategic initiatives are paramount. However, the process of taking experimental observations between model systems and human subjects can be extraordinarily frustrating. We brought together the collective expertise of our mouse and human immunology research programs to reverse engineer a clinical observation into a mouse model system. Our goal was to model (in mice) the age-related impaired delayed-type hypersensitivity response observed in humans, and then evaluate the efficacy of interventions to improve cutaneous immunity. We report here on what worked, what didn’t, and what we learned along the way.
KW - Aging
KW - Delayed-type hypersensitivity
KW - Translational immunology
UR - http://www.scopus.com/inward/record.url?scp=84939898469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939898469&partnerID=8YFLogxK
U2 - 10.1007/s10522-014-9517-0
DO - 10.1007/s10522-014-9517-0
M3 - Article
C2 - 25027761
AN - SCOPUS:84939898469
VL - 16
SP - 203
EP - 208
JO - Biogerontology
JF - Biogerontology
SN - 1389-5729
IS - 2
ER -