Low-Dose d-Amphetamine Induced Regression of Liver Fat Deposits in Dercum Disease

Sehem Ghazala, Jawad Bilal, Elle Ross, Irbaz Bin Riaz, Bobby T Kalb, Karen L. Herbst

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Dercum disease is a rare disorder of painful subcutaneous adipose tissue masses typically presenting as a constellation of signs and symptoms affecting most organs, including slow lymphatic flow and fatty liver. Method: The University of Arizona Institutional Review Board considered this report exempt after patient consent. Multislice, multisequence magnetic resonance imaging (MRI) of the abdomen and pelvis was performed prior to and after d-amphetamine, with and without intravenous gadolinium. Results: Initial MRI demonstrated hepatic steatosis in Case 1; Case 2 had 2-subcentimeter lipid foci within the liver. Initiation of 10-20 mg d-amphetamine decreased liver lipid deposition from 16% to 4% in Case 1 and resolved fat deposits in Case 2 after ~1 year. Conclusion: There is a dire need for novel treatment options for nonalcoholic fatty liver disease to prevent progression to cirrhosis. Reduction of liver fat by d-amphetamine suggests a potential therapeutic role in nonalcoholic fatty liver disease.

Original languageEnglish (US)
JournalAmerican Journal of Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Adiposis Dolorosa
Dextroamphetamine
Fats
Liver
Magnetic Resonance Imaging
Lipids
Research Ethics Committees
Subcutaneous Fat
Gadolinium
Fatty Liver
Pelvis
Abdomen
Signs and Symptoms
Fibrosis
Therapeutics

Keywords

  • Dercum disease
  • Dextroamphetamine
  • Nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Low-Dose d-Amphetamine Induced Regression of Liver Fat Deposits in Dercum Disease. / Ghazala, Sehem; Bilal, Jawad; Ross, Elle; Riaz, Irbaz Bin; Kalb, Bobby T; Herbst, Karen L.

In: American Journal of Medicine, 01.01.2018.

Research output: Contribution to journalArticle

Ghazala, Sehem ; Bilal, Jawad ; Ross, Elle ; Riaz, Irbaz Bin ; Kalb, Bobby T ; Herbst, Karen L. / Low-Dose d-Amphetamine Induced Regression of Liver Fat Deposits in Dercum Disease. In: American Journal of Medicine. 2018.
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