Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury

Asad E Patanwala, Alina Kurita, Elaine Truong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: The primary objective of this study was to determine the effectiveness of a lower dose of levetiracetam (500 mg every 12 hours) to prevent early seizures after traumatic brain injury (TBI). It was hypothesized that the seizure rate would be low and comparable to previous studies using phenytoin.Methods: This was a retrospective cohort study conducted in a tertiary care, academic institution that is designated as a level 1 trauma centre in the US. Consecutive patients with TBI were evaluated. Patients who were given a levetiracetam dose of 500 mg every 12 hours were included. The primary outcome was the occurrence of a seizure within 7 days of TBI.Results: There were a total of 169 patients included in the study, who were treated with levetiracetam 500 mg every 12 hours. The median time to first dose of levetiracetam was 3.5 hours after injury (interquartile range = 1-13 hours). After initiation of levetiracetam, there were four (2.4%) patients who had a seizure within 7 days. This was not significantly different than the hypothesized population value of 3.6% (p = 0.390).Conclusions: A lower dose of levetiracetam 500 mg every 12 hours after TBI may be effective for early seizure prevention after TBI.

Original languageEnglish (US)
Pages (from-to)156-158
Number of pages3
JournalBrain Injury
Volume30
Issue number2
DOIs
StatePublished - Jan 28 2016

Fingerprint

etiracetam
Seizures
Trauma Centers
Phenytoin
Tertiary Healthcare
Traumatic Brain Injury
Dose
Cohort Studies
Retrospective Studies

Keywords

  • Anti-epileptic
  • critically ill
  • dosing
  • neurocritical care

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury. / Patanwala, Asad E; Kurita, Alina; Truong, Elaine.

In: Brain Injury, Vol. 30, No. 2, 28.01.2016, p. 156-158.

Research output: Contribution to journalArticle

Patanwala, Asad E ; Kurita, Alina ; Truong, Elaine. / Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury. In: Brain Injury. 2016 ; Vol. 30, No. 2. pp. 156-158.
@article{b07be608de364bf88bc96aeae6c4e8ee,
title = "Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury",
abstract = "Objective: The primary objective of this study was to determine the effectiveness of a lower dose of levetiracetam (500 mg every 12 hours) to prevent early seizures after traumatic brain injury (TBI). It was hypothesized that the seizure rate would be low and comparable to previous studies using phenytoin.Methods: This was a retrospective cohort study conducted in a tertiary care, academic institution that is designated as a level 1 trauma centre in the US. Consecutive patients with TBI were evaluated. Patients who were given a levetiracetam dose of 500 mg every 12 hours were included. The primary outcome was the occurrence of a seizure within 7 days of TBI.Results: There were a total of 169 patients included in the study, who were treated with levetiracetam 500 mg every 12 hours. The median time to first dose of levetiracetam was 3.5 hours after injury (interquartile range = 1-13 hours). After initiation of levetiracetam, there were four (2.4{\%}) patients who had a seizure within 7 days. This was not significantly different than the hypothesized population value of 3.6{\%} (p = 0.390).Conclusions: A lower dose of levetiracetam 500 mg every 12 hours after TBI may be effective for early seizure prevention after TBI.",
keywords = "Anti-epileptic, critically ill, dosing, neurocritical care",
author = "Patanwala, {Asad E} and Alina Kurita and Elaine Truong",
year = "2016",
month = "1",
day = "28",
doi = "10.3109/02699052.2015.1089596",
language = "English (US)",
volume = "30",
pages = "156--158",
journal = "Brain Injury",
issn = "0269-9052",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Low-dose levetiracetam for seizure prophylaxis after traumatic brain injury

AU - Patanwala, Asad E

AU - Kurita, Alina

AU - Truong, Elaine

PY - 2016/1/28

Y1 - 2016/1/28

N2 - Objective: The primary objective of this study was to determine the effectiveness of a lower dose of levetiracetam (500 mg every 12 hours) to prevent early seizures after traumatic brain injury (TBI). It was hypothesized that the seizure rate would be low and comparable to previous studies using phenytoin.Methods: This was a retrospective cohort study conducted in a tertiary care, academic institution that is designated as a level 1 trauma centre in the US. Consecutive patients with TBI were evaluated. Patients who were given a levetiracetam dose of 500 mg every 12 hours were included. The primary outcome was the occurrence of a seizure within 7 days of TBI.Results: There were a total of 169 patients included in the study, who were treated with levetiracetam 500 mg every 12 hours. The median time to first dose of levetiracetam was 3.5 hours after injury (interquartile range = 1-13 hours). After initiation of levetiracetam, there were four (2.4%) patients who had a seizure within 7 days. This was not significantly different than the hypothesized population value of 3.6% (p = 0.390).Conclusions: A lower dose of levetiracetam 500 mg every 12 hours after TBI may be effective for early seizure prevention after TBI.

AB - Objective: The primary objective of this study was to determine the effectiveness of a lower dose of levetiracetam (500 mg every 12 hours) to prevent early seizures after traumatic brain injury (TBI). It was hypothesized that the seizure rate would be low and comparable to previous studies using phenytoin.Methods: This was a retrospective cohort study conducted in a tertiary care, academic institution that is designated as a level 1 trauma centre in the US. Consecutive patients with TBI were evaluated. Patients who were given a levetiracetam dose of 500 mg every 12 hours were included. The primary outcome was the occurrence of a seizure within 7 days of TBI.Results: There were a total of 169 patients included in the study, who were treated with levetiracetam 500 mg every 12 hours. The median time to first dose of levetiracetam was 3.5 hours after injury (interquartile range = 1-13 hours). After initiation of levetiracetam, there were four (2.4%) patients who had a seizure within 7 days. This was not significantly different than the hypothesized population value of 3.6% (p = 0.390).Conclusions: A lower dose of levetiracetam 500 mg every 12 hours after TBI may be effective for early seizure prevention after TBI.

KW - Anti-epileptic

KW - critically ill

KW - dosing

KW - neurocritical care

UR - http://www.scopus.com/inward/record.url?scp=84958874488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958874488&partnerID=8YFLogxK

U2 - 10.3109/02699052.2015.1089596

DO - 10.3109/02699052.2015.1089596

M3 - Article

VL - 30

SP - 156

EP - 158

JO - Brain Injury

JF - Brain Injury

SN - 0269-9052

IS - 2

ER -