Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation

Véronique D. Bohbot, Milagros S. Copara, Jean Gotman, Arne D. Ekstrom

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Low-Frequency Oscillations (LFO) in the range of 7-9 Hz, or theta rhythm, has been recorded in rodents ambulating in the real world. However, intra-hippocampus EEG recordings during virtual navigation in humans have consistently reported LFO that appear to predominate around 3-4 Hz. Here we report clear evidence of 7-9 Hz rhythmicity in raw intra-hippocampus EEG traces during real as well as virtual movement. Oscillations typically occur at a lower frequency in virtual than real world navigation. This study highlights the possibility that human and rodent hippocampal EEG activity are not as different as previously reported and this difference may arise, in part, due to the lack of actual movement in previous human navigation studies, which were virtual.

Original languageEnglish (US)
Article number14415
JournalNature communications
Volume8
DOIs
StatePublished - Feb 14 2017
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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