Lower extremities magnetic resonance angiography with blood pressure cuff compression: Quantitative dynamic analysis

Marcel Koenigkam-Santos, Puneet Sharma, Bobby Kalb, John Carew, John N. Oshinski, Diego Martin

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: To quantitatively evaluate changes induced by the application of a femoral blood-pressure cuff (BPC) on run-off magnetic resonance angiography (MRA), which is a method generally previously proposed to reduce venous contamination in the leg. Materials and Methods: This study was Health Insurance Portability and Accountability Act (HIPAA)- and Institutional Review Board (IRB)-compliant. We used time-resolved gradient-echo gadolinium (Gd)-enhanced MRA to measure BPC effects on arterial, venous, and soft-tissue enhancement. Seven healthy volunteers (six men) were studied with the BPC applied at the mid-femoral level unilaterally using a 1.5T MR system after intravenous injection of Gd-BOPTA. Different statistical tools were used such as the Wilcoxon signed rank test and a cubic smoothing spline fit. Results: We found that BPC application induces delayed venous filling (as previously described), but also induces significant decreases in arterial inflow, arterial enhancement, vascular-soft tissue contrast, and delayed peak enhancement (which have not been previously measured). Conclusion: The potential benefits from using a BPC for run-off MRA must be balanced against the potential pitfalls, elucidated by our findings.

Original languageEnglish (US)
Pages (from-to)1450-1456
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume29
Issue number6
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Keywords

  • Gadolinium
  • MRA
  • Magnetic resonance angiography
  • Run-off MRA
  • Time-resolved imaging
  • Venous contamination

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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