Lower physical activity is associated with skeletal muscle fat content in girls

Joshua Nicholas Farr, Marta D. Van Loan, Timothy G Lohman, Scott B Going

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Fat contained within skeletal muscle is strongly associated with obesity, type 2 diabetes mellitus, and metabolic syndrome. Physical inactivity may be a risk factor for greater fat infiltration within skeletal muscle during growth. Purpose: We sought to examine the relationship between physical activity and skeletal muscle fat content of the calf and thigh in girls. Methods: Data from 464 girls, age 8-13 yr, were used to examine the relationship between physical activity and skeletal muscle fat content of the calf and thigh. Calf and thigh muscle density (mg•cm), an index of skeletal muscle fat content, was assessed at the 66% tibia and 20% femur sites relative to the respective distal growth plates of the nondominant limb using peripheral quantitative computed tomography. Physical activity level was classified by past-year physical activity questionnaire score. Results: Muscle densities of the calf and thigh were inversely correlated with percent total body fat (r =-0.37 and-0.48, P values < 0.001) and total body fat mass (r =-0.33 and-0.40, P values < 0.001). Multiple linear regression with physical activity, ethnicity, maturity offset, and muscle cross-sectional area as independent variables showed that physical activity was independently associated with muscle densities of the calf (β = 0.14, P = 0.002) and thigh (β = 0.15, P < 0.001). Thus, lower physical activity was associated with higher skeletal muscle fat content. Conclusions: Our results suggest that a lower level of physical activity may lead to excess skeletal muscle fat content of the calf and thigh in girls.

Original languageEnglish (US)
Pages (from-to)1375-1381
Number of pages7
JournalMedicine and Science in Sports and Exercise
Volume44
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Skeletal Muscle
Thigh
Fats
Exercise
Muscles
Adipose Tissue
Growth Plate
Tibia
Femur
Type 2 Diabetes Mellitus
Linear Models
Extremities
Obesity
Tomography
Growth

Keywords

  • exercise
  • female
  • Muscle quality
  • pqct
  • youths

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Lower physical activity is associated with skeletal muscle fat content in girls. / Farr, Joshua Nicholas; Van Loan, Marta D.; Lohman, Timothy G; Going, Scott B.

In: Medicine and Science in Sports and Exercise, Vol. 44, No. 7, 07.2012, p. 1375-1381.

Research output: Contribution to journalArticle

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